Neuroinformatics

, Volume 3, Issue 2, pp 163–166 | Cite as

A new era in computational neuroscience

  • Kim T. Blackwell

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References

  1. Bhalla US. (2004a) Signaling in small subcellular volumes. I. Stochastic and diffusion effects on individual pathways. Biophys. J. 87: 733–44.PubMedCrossRefGoogle Scholar
  2. Bhalla US. (2004b) Signaling in small subcellular volumes. II. Stochastic and diffusion effects on synaptic network properties. Biophys. J. 87:745–53.PubMedCrossRefGoogle Scholar
  3. Bhalla US, Iyengar R (1999) Emergent properties of networks of biological signaling pathways. Science 283: 381–387.PubMedCrossRefGoogle Scholar
  4. Blackwell KT. (2004) Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda. J. Comput. Neurosci. 17: 81–99.PubMedCrossRefGoogle Scholar
  5. Blackwell K.T., Hellgren Kotaleski J (2002) Modeling the dynamics of second messenger pathways. In Neuroscience Databases: A Practical Guide, Ed. R. Kotter. Kluwer Academic Publishers, Norwell, MA.Google Scholar
  6. Blumenfeld H, Zablow L, Sabatini B. (1992) Evaluation of cellular mechanisms for modulation of calcium transients using a mathematical model of fura-2 Ca2+ imaging in Aplysia sensory neurons. Biophys J. 63:1146–64.PubMedCrossRefGoogle Scholar
  7. Bower JM, Beeman D (1998) The Book of Genesis: Exploring Realistic Neural Models with the GEneral NEural Slmulation System. New York: Springer-Verlag.Google Scholar
  8. De Schutter and Bower (1994) An active membrane model of the cerebellar Purkinje cell I. Simulation of current clamps in slice. J Neurophysiology 71:375–400.Google Scholar
  9. Harris KM (1999) Structure, development, and plasticity of dendritic spines. Curr Opin Neurobiol. 9:343–8.PubMedCrossRefGoogle Scholar
  10. Hines ML, Carnevale NT (2000) Expanding NEURON’s repertoire of mechanisms with NMODL. Neural Computation 12:839–851.CrossRefGoogle Scholar
  11. Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 177:500–544.Google Scholar
  12. Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997) K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387:869–75.PubMedCrossRefGoogle Scholar
  13. Holmes WR, Levy WB. (1990) Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes. J Neurophysiol. 63:1148–68.PubMedGoogle Scholar
  14. Poirazi P, Brannon T, Mel BW. (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37: 977–87.PubMedCrossRefGoogle Scholar
  15. Rall (1969) Time constants and the electronic length of membrane cylinders and neurons. Biophysical Journal 9:1483–1509.PubMedGoogle Scholar
  16. Rosenmund C, Carr DW, Bergeson SE, Nilaver G, Scott JD, Westbrook GL. (1994) Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature 368: 853–6.PubMedCrossRefGoogle Scholar
  17. Scorcioni R, Boutiller JM, Ascoli GA (2002) A real scale model of the dentate gyrus based on single-cell reconstructions and 3D rendering of a brain atlas. Neurocomputing 44–46:629–634.CrossRefGoogle Scholar
  18. Stiles JR, Bartol TM. (2001) Monte Carlo methods for simulating realistic synaptic microphysiology using MCell. In De Schutter E, editor. Computational Neuroscience: Realistic Modeling for Experimentalists. CRC Press: 87–127.Google Scholar
  19. Westphal RS, Anderson KA, Means AR, Wadzinski BE. (1998) A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. Science 280: 1258–61.PubMedCrossRefGoogle Scholar
  20. Zhou L, Chiu SY (2001) Computer model for action potential propagation through branch point in myelinated nerves J Neurophysiol. 85: 197–210.PubMedGoogle Scholar

Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Kim T. Blackwell
    • 1
  1. 1.School of Computational Sciences, and the Krasnow Institute of Advanced Studies, Rockfish Creek LaneMS 2AI George Mason UniversityFairfax

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