EMAP and EMAGE
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The Edinburgh Mouse Atlas Project (EMAP) is a time-series of mouse-embryo volumetric models. The models provide a context-free spatial framework onto which structural interpretations and experimental data can be mapped. This enables collation, comparison, and query of complex spatial patterns with respect to each other and with respect to known or hypothesized structure. The atlas also includes a time-dependent anatomical ontology and mapping between the ontology and the spatial models in the form of delineated anatomical regions or tissues. The models provide a natural, graphical context for browsing and visualizing complex data.
The Edinburgh Mouse Atlas Gene-Expression Database (EMAGE) is one of the first applications of the EMAP framework and provides a spatially mapped gene-expression database with associated tools for data mapping, submission, and query. In this article, we describe the underlying principles of the Atlas and the gene-expression database, and provide a practical introduction to the use of the EMAP and EMAGE tools, including use of new techniques for whole body gene-expression data capture and mapping.
Index EntriesMouse development developmental atlas gene-expression database ontology 3D image viewer Java interfaces
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- Baldock, R. A. and Hill, W. (1999) Image Warping and Spatial Data Mapping, Image Processing and Analysis: A Practical Approach. (Baldock, R. A. and Graham, J., eds.) Oxford University Press, Oxford, UK, pp. 261–288Google Scholar
- Downes, K. M. and Davies, T. (1993) Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development 118, 1255–1266.Google Scholar
- Kaufman, M. H. (1992) The Atlas of Mouse Development, Academic Press, London, UK.Google Scholar
- Theiler, K. (1989) The house mouse: Atlas of embryonic development. Springer Verlag, New York.Google Scholar