Bone marrow hyaluronan distribution in patients with acute myeloid leukemia
- 85 Downloads
Acute myeloid leukemia (AML) is a clonal disorder characterized by abnormal proliferation of myeloid cell precursors. Research has mainly focused on the cellular events, but the bone marrow matrix has attracted minor interest. In this study bone marrow biopsies were obtained from 35 newly diagnosed AML patients. The bone marrows were analyzed regarding the occurrence and distribution of hyaluronan (HYA) and reticulin fibers (type III collagen). The bone marrow sections were analyzed histochemically and compared with bone marrows from 30 healthy controls. The HYA staining was significantly stronger in the AML patients compared with the controls. Only one patient demonstrated abnormal reticulin staining score, but in the group of patients with antecedent myelodysplastic syndrome (MDS), the reticulin staining score was significantly higher compared with the patients with de novo AML. There was a significant correlation between the HYA staining and reticulin staining scores in the AML patients as was seen in the control group.
Key WordsBone marrow acute myeloid leukemia hyaluronan
Unable to display preview. Download preview PDF.
- 6.Ponta H, Sherman L, Herrlich P. CD44: From adhesion molecules to signaling regulators. Nature 2003;4:33–45.Google Scholar
- 10.Jaffe E, Harris N, Stein H, Vardiman J. (eds). World Health Organization Classification of Tumours. Pathology and genetics of tumours of haematopoetic and lymphoid tissues. IARC Press, Lyon, France, 2001, pp. 76–80.Google Scholar
- 12.Bain BJ, Clark DM, Lampert IA. Bone marrow pathology. Blackwell Science: Oxford, 2001.Google Scholar
- 13.Putt FA. Manual of histological staining methods. John Wiley & Sons: New York, 1972, p. 107.Google Scholar
- 17.Avigdor A, et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 103(8):2981–2989.Google Scholar