Medical Oncology

, Volume 20, Issue 3, pp 233–236 | Cite as

High prevalence of MMTV-like env gene sequences in gestational breast cancer

  • Y. Wang
  • S. M. Melana
  • B. Baker
  • I. Bleiweiss
  • M. Fernandez-Cobo
  • J. F. Mandeli
  • J. F. Holland
  • B. G. T. Pogo
Original Article

Abstract

Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30–38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.

Key Words

Gestational breast cancer MMTV sequences 

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Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • Y. Wang
    • 1
  • S. M. Melana
    • 1
  • B. Baker
    • 1
  • I. Bleiweiss
    • 2
  • M. Fernandez-Cobo
    • 1
  • J. F. Mandeli
    • 3
  • J. F. Holland
    • 1
  • B. G. T. Pogo
    • 1
    • 4
  1. 1.Department of MedicineThe Mount Sinai School of MedicineNew York
  2. 2.Department of PathologyThe Mount Sinai School of MedicineNew York
  3. 3.Biomathematical SciencesThe Mount Sinai School of MedicineNew York
  4. 4.Department of MicrobiologyThe Mount Sinai School of MedicineNew York

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