High prevalence of MMTV-like env gene sequences in gestational breast cancer
- 96 Downloads
Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30–38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.
Key WordsGestational breast cancer MMTV sequences
Unable to display preview. Download preview PDF.
- 2.Pogo BGT, Holland JF. Human tumor viruses and breast cancer. A review. J Women’s Cancer 2002;4(2):141–147.Google Scholar
- 5.Wang, Y, et al. MMTV-like env gene sequences in human breast cancer. Arch Virol 2001;145:1–10.Google Scholar
- 14.Wang Y, Pelisson I, Melana SM, Holland JF, Pogo BGT. Detection of MMTV-like LTR and LTR env gene sequences in human breast cancer. Int J Oncology 2001;18:1041–1044.Google Scholar
- 21.Ford CE, et al. Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women. Clin Cancer Res 2020;9:1118–1120.Google Scholar
- 23.Stewart THM, et al. Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus. Br J Cancer 2000;82:446–451.Google Scholar