Medical Oncology

, Volume 19, Issue 4, pp 267–272 | Cite as

A study of bacteremia in febrile neutropenic patients at a tertiary-care hospital with special reference to anaerobes

  • P. Mathur
  • R. Chaudhry
  • L. Kumar
  • A. Kapil
  • B. Dhawan
Original Article

Abstract

Patients with hematological malignancies who are receiving chemotherapy suffer prolonged periods of neutropenia, which leads to a greater risk of infection and mortality. A prospective study was conduced to determine the incidence of bacteremia in patients of hematological malignancies over a 2-yr period. A total of 119 episodes of febrile neutropenia occurred among 96 consecutive patients, of which 35 episodes were associated with bacteremia. Forty-four percent of the isolated bacteria were Gram-positive aerobes and 46% were Gram-negative aerobes. Staphylococcus aureus, Enterococcus spp., and Escherichia coli were the most common isolates. Gram-negative bacteremia was associated with a higher mortality. Anaerobes accounted for 4.4% of all isolates. The episodes of anaerobic bacteremia were polymicrobial and had a fatal outcome. A high incidence of antimicrobial resistance among aerobic and anaerobic bacteria was also recorded. Compared to previous years, a shift from a predominating Gram-negative to a Gram-positive etiology was noted. The initial empiric antibiotic regimens should be based on a local knowledge of the most common causative microorganisms, their sensitivity pattern, and the outcome of bacteremia.

Key Words

Bacteremia febrile neutropenia hematological malignancies anaerobes antimicrobial resistance 

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Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • P. Mathur
    • 1
  • R. Chaudhry
    • 1
  • L. Kumar
    • 2
  • A. Kapil
    • 1
  • B. Dhawan
    • 1
  1. 1.Department of MicrobiologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of Medical OncologyAll India Institute of Medical SciencesNew DelhiIndia

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