Molecular Neurobiology

, Volume 30, Issue 1, pp 35–47

The role of BETA2/NeuroD1 in the development of the nervous system

Article

Abstract

BETA2/NeuroD1 is a member of the basic helix-loop-helix (bHLH) transcription factor family, which has been shown to play a major role in development of the nervous system and formation of the endocrine system. Gain-of-function studies have indicated that BETA2/NeuroD1 is important for the neurogenesis of Xenopus embryos and several neurogenic cell lines. Disruption of the gene encoding BETA2/NeuroD1 leads to severe abnormalities of the developing mouse central nervous system as well as the peripheral nervous system. The focus of this article is on the recent progress in understanding the role of BETA2/NeuroD1 in the development of the nervous system.

Index Entries

BETA2 NeuroD1 bHLH CNS PNS neurogenesis 

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Copyright information

© Humana Press Inc 2004

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiologyBaylor College of MedicineHouston
  2. 2.Department of Program of DevelopmentBaylor College of MedicineHouston

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