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Molecular Biotechnology

, Volume 30, Issue 1, pp 57–69 | Cite as

Molecular biology of the blood-brain barrier

  • William M. Pardridge
Review

Abstract

Molecular biological investigations into the brain capillary endothelium and microvasculature, which forms the blood-brain barrier (BBB) in vivo, can provide the platform for the discovery and the molecular cloning of BBB-specific genes. Novel BBB genes can be discovered with either a genomics-based approach such as subtractive suppressive hybridization, or a proteomics approach using subtractive antibody expression cloning. BBB-specific genes are disproportionately transporter genes encoding either for carrier-mediated transporters, active efflux transporters, or receptor-mediated transporters. The discovery of new BBB transporters can lead to the development of new approaches to brain drug delivery using endogenous brain endothelial transporters.

Index Entries

Blood-brain barrier (BBB) endothelium drug delivery genomics proteomics 

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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  1. 1.Department of MedicineUCLALos AngelesUSA

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