Molecular Biotechnology

, Volume 25, Issue 1, pp 37–43

Laser immunotherapy

A novel treatment modality for metastatic tumors
  • Wei R. Chen
  • Raoul Carubelli
  • Hong Liu
  • Robert E. Nordquist


Laser immunotherapy is a novel approach for the treatment of metastatic tumors. It combines a selective photothermal laser-tissue interaction for direct tumor destruction and an immunoadjuvant-directed simulation for immune responses. In experiments using a rat metastatic tumor model, laser immunotherapy resulted in the eradication of both treated primary tumors and untreated metastases at remote sites. It also induced anti-tumor resistance.

Index Entries

Near-infrared laser indocyanine green glycated chitosan DMBA-4 metastatic rat tumor photothermal laser tissue interaction immunological stimulation laser immunotherapy 


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Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • Wei R. Chen
    • 1
    • 2
  • Raoul Carubelli
    • 3
  • Hong Liu
    • 4
  • Robert E. Nordquist
    • 3
  1. 1.Biomedical Engineering Program, Department of Physics and EngineeringUniversity of Central OklahomaEdmond
  2. 2.Department of Physics and AstronomyUniversity of OklahomaNorman
  3. 3.Wound Healing of Oklahoma, Inc.Oklahoma City
  4. 4.Center for Bioengineering and School of Electrical and Computer EngineeringUniversity of OklahomaNorman

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