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Molecular Biotechnology

, Volume 24, Issue 1, pp 27–39 | Cite as

Historical perspective of the renin-angiotensin system

  • John E. HallEmail author
Review

Abstract

Researchers continue to be fascinated with the renin-angiotensin system (RAS) more than 100 yr after its discovery because of its powerful role in controlling sodium balance, body fluid volumes, and arterial pressure. Development of drugs that block different components of this system has led to powerful treatments for hypertension, heart failure, diabetes, and other diseases. Molecular approaches to studying this system offer new possibilities for better understanding the physiology and pathophysiology of the RAS, and for developing new therapeutic paradigms. Our challenge in the future will be to effectively utilize the technological advances that are taking place in virtually all areas of science, including the RAS, and to translate them into a better understanding of the pathophysiology and treatment of human diseases.

Index Entries

Kidney angiotensin II hypertension sodium excretion 

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Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  1. 1.Department of Physiology and BiophysicsUniversity of Mississippi Medical CenterJackson

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