Advertisement

Journal of Molecular Neuroscience

, Volume 30, Issue 1–2, pp 219–222 | Cite as

Acetylcholine, cognition, and consciousness

  • Nancy J. WoolfEmail author
Original Article

Keywords

Actin Filament Basal Forebrain Molecular Neuroscience Volume Tubulin Subunit Dendri 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bjornstrom K. and Eintrei C. (2003) The difference between sleep and anaesthesia is in the intracellular signal: propofol and GABA use different subtypes of the GABA(A) receptorbeta subunit and vary in their interaction with actin. Acta Anaesthesiol Scand 47, 157–164.PubMedCrossRefGoogle Scholar
  2. Butcher L. L. and Woolf N. J. (2004) Cholinergic neurons and networks revisited. In The Rat Central Nerobus System, Paxinos, G. W., ed. Elsevier Academic, San Francisco: pp. 1257–1268.Google Scholar
  3. Chen J., Kanai Y., Cowan N. J., and Hirokawa N. (1992) Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature 360, 674–677.PubMedCrossRefGoogle Scholar
  4. Dombeck D. A., Kasischke K. A., Vishwasrao H. d., Ingelsson M., Hyman B. T., and Webb W. W. (2003) Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy. Proc. Natl. Acad. Sci. U.S.A. 100, 7081–7086.PubMedCrossRefGoogle Scholar
  5. Gaidarzhy A., Zolfagharkhani G., Badzey R. L., and Mohanty P. (2005) Evidence for quantized displacement in macroscopic nanomechanical oscillators. Phys. Rev. Lett. 94, 030402.PubMedCrossRefGoogle Scholar
  6. Hagan S., Hameroff S. R., and Tuszynski J. A. (2002) Quantum computation in brain microtubules: decoherence and biological feasibility. Phys. Rev. E. Stat. Nonlinear Soft Matter Phys. 65, 061901.Google Scholar
  7. Hameroff S. (1998) Anesthesia, consciousness and hydrophobic pockets—a unitary quantum hypothesis of anesthetic action. Toxicol. Lett. 100–101, 31–39.PubMedCrossRefGoogle Scholar
  8. Kaech S., Brinkhaus H., and Matus A. (1999) Volatile anesthetics block actin-based motility in dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 96, 10,433–10,437.CrossRefGoogle Scholar
  9. Kehr J., Yoshitake T., Wang F. H., Wynick D., Holmberg K., Lendahl U., et al. (2001) Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice. J. Neurosci. Methods 109, 71–80.PubMedCrossRefGoogle Scholar
  10. Khuchua Z., Wozniak D. F., Bardgett M. E., Yue, Z., McDonald M., Boero J., et al. (2003) Deletion of the N-terminus of murine MAP2 by gene targeting disrupts hippocampal Ca1 neuron architecture and alters contextual memory. Neuroscience 119, 101–111.PubMedCrossRefGoogle Scholar
  11. Mershin A., Kolomenski A. A., Schuessler H. A., and Nanopoulos D. V. (2004) Tubulin dipole moment, dielectric constant and quantum behavior: computer simultations, experimental results and suggestions. Biosystems 77, 73–85.PubMedCrossRefGoogle Scholar
  12. Mukhopadhyay R., Kumar S., and Hoh J. H., (2004) Molecular mechanisms for organizing the neuronal cytoskeleton. Bioessays 26, 1017–1025.PubMedCrossRefGoogle Scholar
  13. Parvizi J. and Damasio A. R. (2003) Neuronatomical correlates of brainstem coma. Brain 126, 1524–1536.PubMedCrossRefGoogle Scholar
  14. Penrose R. (1994) Shadows of the Mind. Oxford University Press, Oxford, UK.Google Scholar
  15. Santarella R. A., Skiniotis, G., Goldie K. N. Tittmann, P., Gross H., Mandelkow E. M., et al. (2004) Surface-decoration of microtubules by human tau. J. Mol. Biol. 339, 539–553.PubMedCrossRefGoogle Scholar
  16. Tegmark M. (2000) Importance of quantum decoherence in brain processes. Phys. Rev. E Stat. Phys. Plasmas Fluids Related Interdisciplinary Top. 61, 4194–4206.Google Scholar
  17. Tuszynski J. A., Brown J. A., and Hawrylak P. (1998) Dielectric polization, electrical conduction, information processing and quantum computation in microtubules. Are they plausible? Philos. Trans. R. Soc. London Ser. A. 356, 1897.CrossRefGoogle Scholar
  18. Tuszynski J. A., Portet S., Dixon J. M., Luxford C., and Cantiello H. F. (2004) Ionic wave propagation along actin filaments. Biophys J. 86, 1890–1903.PubMedCrossRefGoogle Scholar
  19. Vaillant A. R., Zanassi P., Walsh G. S., Aumont A., Alonso A., and Miller F. D. (2002) Signaling mechanisms underlying reversible, activity-dependent dendrite formation. Neuron 34, 985–998.PubMedCrossRefGoogle Scholar
  20. Woolf N. J. (1998) A structural basis for memory storage in mammals. Prog. Neurobiol. 55, 59–77.PubMedCrossRefGoogle Scholar
  21. Woolf N. J. and Hameroff S. R. (2001) A quantum approach to visual consciousness. Trends Cogn. Sci. 5, 472–478.PubMedCrossRefGoogle Scholar
  22. Woolf N. J., Zinnerman M. D., and Johnson G. V. (1999) Hippocampal microtubule-associated protein-2 alterations with contextual memory. Brain Res. 821, 241–249.PubMedCrossRefGoogle Scholar

Copyright information

© Human Press Inc 2006

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of California at Los AngelesLos Angeles

Personalised recommendations