Journal of Molecular Neuroscience

, Volume 27, Issue 3, pp 311–314

No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from Southern Italy

  • Giulia Bellini
  • Carmela Bravaccio
  • Filippo Calamoneri
  • Maria Donatella Cocuzza
  • Pasquale Fiorillo
  • Antonella Gagliano
  • Domenico Mazzone
  • Emanuele Miraglia del Giudice
  • Geoffredo Scuccimarra
  • Roberto Militerni
  • Antonio Pascotto
Original Article

Abstract

Recently, DYX1C1, a candidate gene for developmental dyslexia, encoding a nuclear tetratricopepetide repeat domain protein dynamically regulated in brain, has been characterized through a translocation breakpoint in a Finnish family. Two putatively functional variants, −3G/A and 1249G/T, have been reported to be significantly associated with dyslexia in this population. Further studies, conducted on different ethnic groups (English and Canadian), have not confirmed a role for DYX1C1 variants in increasing the risk for dyslexia. We investigated the role of these variants in dyslexic children and adolescents from Southern Italy. No significant evidence for association between dyslexia and these DYX1C1 putative functional variants has been shown. We argue that the different DYX1C allele frequencies shown among Italian and Finnish subjects with dyslexia could be attributable to the different linkage disequilibrium structure of these populations.

Index Entries

EKN1 reading disabilities SNPs 15q21 dyslexia DYX1C1 

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Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Giulia Bellini
    • 1
    • 2
  • Carmela Bravaccio
    • 1
  • Filippo Calamoneri
    • 3
  • Maria Donatella Cocuzza
    • 4
  • Pasquale Fiorillo
    • 5
  • Antonella Gagliano
    • 3
  • Domenico Mazzone
    • 4
  • Emanuele Miraglia del Giudice
    • 2
  • Geoffredo Scuccimarra
    • 6
  • Roberto Militerni
    • 1
  • Antonio Pascotto
    • 1
  1. 1.Chair of Child NeuropsychiatrySecond University of NaplesNaplesItaly
  2. 2.Department of PediatricsSecond University of NaplesNaplesItaly
  3. 3.Chair of Child NeuropsychiatryUniversity of MessinaMessinaItaly
  4. 4.Chair of Child NeuropsychiatryUniversity of CataniaCataniaItaly
  5. 5.Centro SerapidePozzuoli (Naples)Italy
  6. 6.Istituto AntonianoErcolano (Naples)Italy

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