Based on genetic findings, the relationship between the APP/Aβ and tau/tangle pathologies are discussed. It is argued that APP/Aβ is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Aβ can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.
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Hardy, J. The relationship between amyloid and tau. J Mol Neurosci 20, 203–206 (2003). https://doi.org/10.1385/JMN:20:2:203
- tau, genetic
- Alzheimer’s disease
- Pick’s disease