Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture
- 245 Downloads
Herbal products are being increasingly used as dietary supplements and therapeutic agents. However, much more research must be performed in order to determine the biological basis for their putative clinical effects. We tested the effects of milk thistle (Silybum marianum) extract on the differentiation and survival of cultured neural cells. Milk thistle enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC-12 neural cells and prolonged their survival in culture. Milk thistle extract also protected cultured rat hippocampal neurons against oxidative stress-induced cell death. Our data demonstrate that milk thistle extract can promote neuronal differentiation and survival, suggesting potential benefits of chemicals in this plant on the nervous system.
Index EntriesApoptosis herbal medicine hippocampus neurite outgrowth oxidative stress
Unable to display preview. Download preview PDF.
- Brevoort P. (1996) The U.S. botanical market: an overview. Herbalgram 36, 49–57.Google Scholar
- Park, D.S., Stefanis, L., Yan, C.Y., Farinelli, S.E., and Greene, L.A. (1996) Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. J. Biol. Chem. 271, 21898–21905.PubMedCrossRefGoogle Scholar
- Zhao J., Sharma Y., and Agarwal R. (1999) Significant inhibition by the Flavinoid antioxidant Silymarin against 12-O-tetradecanoylphorbol 13-Acetate caused modulation of antioxidant and inflammatory enzymes and Cyclooxygenase 2 and Interleukin-1α expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol. Carcinogen. 26, 321–333.CrossRefGoogle Scholar