Journal of Molecular Neuroscience

, Volume 16, Issue 2–3, pp 117–121 | Cite as

Role of CD36 in membrane transport and utilization of long-chain fatty acids by different tissues

  • Chris T. Coburn
  • Tahar Hajri
  • Azeddine Ibrahimi
  • Nada A. Abumrad
Article

Abstract

The transmembrane glycoprotein CD36 has been identified in isolated cell studies as a putative transporter of long-chain fatty acids. To examine the physiological role of CD36, we studied FA uptake and metabolism by tissues of CD36 null mice after injection with two fatty acid analogs. Compared to controls, uptake was substantially reduced (50–80%) in heart, skeletal muscle, and adipose tissues of null mice. The reduction in uptake was associated with a large decrease in fatty acid incorporation into triglycerides, which could be accounted for by an accumulation of diacylglycerides. Thus CD36 facilitates a major fraction of fatty acid uptake by myocardial, skeletal muscle, and adipose tissues, where it is highly expressed. Its role in other tissues where its expression is low and cell-specific could not be determined in these studies.

Index Entries

CD36 FAT FA transport BMIPP IPPA heart adipose triglyceride 

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Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • Chris T. Coburn
    • 1
  • Tahar Hajri
    • 1
  • Azeddine Ibrahimi
    • 1
  • Nada A. Abumrad
    • 1
  1. 1.Departments of Physiology and BiophysicsState University of New York at Stony BrookNY

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