Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles
- Cite this article as:
- Wieckowski, E. & Whiteside, T.L. Immunol Res (2006) 36: 247. doi:10.1385/IR:36:1:247
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.