Immunologic Research

, Volume 35, Issue 3, pp 263–277 | Cite as

The CD94/NKG2 family of receptors

From molecules and cells to clinical relevance
  • Francisco Borrego
  • Madhan Masilamani
  • Alina I. Marusina
  • Xiaobin Tang
  • John E. Coligan

Abstract

Immune responses must be tightly regulated to avoid hyporesponsiveness on one hand or excessive inflammation and the development of autoimmunity (hyperresponsiveness) on the other hand. This balance is attained through the throttling of activating signals by inhibitory signals that ideally leads to an adequate immune response against an invader without excessive and extended inflammatory signals that promote the development of autoimmunity. The CD94/NKG2 family of receptors is composed of members with activating or inhibitory potential. These receptors are expressed predominantly on NK cells and a subset of CD8+T cells, and they have been shown to play an important role in regulating responses against infected and tumori genic cells. In this review, we discuss the current knowledge about this family of receptors, including ligand and receptor interaction, signaling, membrane dynamics, regulation of gene expression and their roles in disease regulation, infections, and cancer, and bone marrow transplantation.

Key Words

CD94/NKG2 DAP12 HLA-E NK cells CD8+T cells 

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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Francisco Borrego
    • 1
  • Madhan Masilamani
    • 1
  • Alina I. Marusina
    • 1
  • Xiaobin Tang
    • 1
  • John E. Coligan
    • 1
  1. 1.Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthRockville

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