Immunologic Research

, Volume 35, Issue 3, pp 233–248

Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease

  • Michael R. Batzloff
  • Manisha Pandey
  • Colleen Olive
  • Michael F. Good

Abstract

Rheumatic fever (RF) and rheumatic heart disease (RHD) are post-infectious complications of an infection (or repeated infection) with the Gram-positive bacterium Streptococcus pyogenes (also known as group A streptococcus, GAS). RF and RHD are global problems and affect many indigenous populations of developed countries and many developing countries. However, RF and RHD are only part of a larger spectrum of diseases caused by this organism. The development of a vaccine against GAS has primarily targeted the abundant cell-surface protein called the M-protein. This review focuses on different M-protein-based-subunit vaccine approaches and the different delivery technologies used to administer these vaccine candidates in preclinical studies.

Key Words

Peptide Vaccine Streptococcus Lipids Conjugation Antimicrobials 

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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Michael R. Batzloff
    • 1
  • Manisha Pandey
    • 1
  • Colleen Olive
    • 1
  • Michael F. Good
    • 1
  1. 1.The Cooperative Research Centre for Vaccine Technology and the Australian Centre for International Tropical Health and Nutrition, The Queensland Institute of Medical ResearchPost Office Royal Brisbane HospitalBrisbaneAustralia

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