Immunologic Research

, Volume 31, Issue 1, pp 47–55 | Cite as

PI3K/AKT signaling and systemic autoimmunity

  • Rahul K. Patel
  • Chandra Mohan
Article

Abstract

The phosphoinositide 3-kinase (PI3K)/Akt signaling axis plays an important role in cellular proliferation and growth signaling. With respect to the immune system, a growing body of data is helping to elucidate the role of this pathway in lymphocyte development, as well as to show how perturbations that lead to unregulated activation in this pathway may produce systemic autoimmunity or malignancy. Various knockout and transgenic murine models have been described for key mediators of this signaling pathway. Many of these models resulting in the activation of this pathway demonstrate features of systemic autoimmunity linking this pathway to autoimmune disease. Here, we review recently described murine models that exhibit activated PI3K/Akt signaling and the potential role this pathway in autoimmune disease, and also discuss the therapeutic implications of these findings.

Key Words

PI3K PTEN PIP3 Akt mTOR Autoimmunity 

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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Rahul K. Patel
    • 1
  • Chandra Mohan
    • 1
  1. 1.Department of RheumatologyUT Southwestern Medical Center at DallasDallas

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