Immunologic Research

, Volume 28, Issue 3, pp 181–191

Antibody-induced transplantation tolerance

The role of dominant regulation
  • Luis Graca
  • Alain Le Moine
  • Stephen P. Cobbold
  • Herman Waldmann
Article

Abstract

A short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and the tolerated graft. The nature of such regulatory T cells, their relationship to CD4+CD25+ T cells, and their mode of action have all been the subjects of much attention recently. Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy.

Key Words

Regulatory T cells CD4+CD25+ Therapeutic antibodies Infectious tolerance 

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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Luis Graca
    • 1
  • Alain Le Moine
    • 1
  • Stephen P. Cobbold
    • 1
  • Herman Waldmann
    • 1
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

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