Immunologic Research

, Volume 28, Issue 1, pp 25–37 | Cite as

The function role of GATA-3 in Th1 and Th2 differentiation

  • Meixia Zhou
  • Wenjun Ouyang
Article

Abstract

GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6. GATA-3 regulates Th2 cytokine expression notonly at the transcription level, such asdirectly binding to the promoters of the IL-5 and IL-13 gene, but also by the involvement in the remodeling of the chromatin structure and opening the IL-4 locus. As a master control, GATA-3 stabilizes the Th2 phenotype by two methods. First, GATA-3 shuts down Th1 development through the repression the IL-12 receptor β2-chain expression. Second, GATA-3 augments its own expression by a positive feedback autoregulation. In this article, we review the recent study of the function of GATA-3 in Th1 and Th2 differentiation.

Key Words

Th1 Th2 GATA-3 Cytokines IFN-γ IL-4 Transcription factors 

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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Meixia Zhou
    • 1
  • Wenjun Ouyang
    • 2
  1. 1.Department of PathologyWashington University School of MedicineSt. Louis
  2. 2.Department of ImmunologyGenentech, Inc.South San Francisco

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