Immunologic Research

, Volume 27, Issue 2–3, pp 309–329 | Cite as

Role of the BCR complex in B cell development, activation, and leukemic transformation

  • Susan R. Rheingold
  • Valerie I. Brown
  • Junjie Fang
  • Jenny M. Kim
  • Stephan A. Grupp
Article

Abstract

A primary focus of signal transduction in B cells, from the pre-B cell to the mature B cell, is the B cell receptor complex. Here we describe work demonstrating the importance of signaling via the pre-B cell receptor complex (pre-BCR) to the pre-B cell transition, the central checkpoint in B-cell development. We have shown tht pre-BCR complex components Igα and Igβ are critical to allowing the pre-B cell to move through thistransition, but may not be required for allelic exclusion. Pre-BCR expression also directly affects the response of leukemic cells to steroid treatment, suggesting that signals initiated by the pre-BCR complex may present therapeutic targetsin acute leukemia. Additionally, interleukin-7 may also modulate the response of leukemic cells arising from early B-cell stages to treatment. This observation has lead directly to proposals to test drugs which may antagonize early B-cell growth signals, such as rapamycin, in acute lymphoid leukemia.

Key Words

B cell receptor complex Pre-B cell receptor Cytoplasmic μ B-cell development 

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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Susan R. Rheingold
    • 1
    • 2
  • Valerie I. Brown
    • 1
    • 2
  • Junjie Fang
    • 1
  • Jenny M. Kim
    • 3
  • Stephan A. Grupp
    • 1
    • 2
  1. 1.Division of OncologyChildren's Hospital of PhiladelphiaPhiladelphia
  2. 2.School of MedicineUniversity of PennsylvaniaPhiladelphia
  3. 3.Division of Hematology/OncologyChildren's HospitalSan Diego

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