Immunologic Research

, Volume 26, Issue 1–3, pp 35–43

B cell-restricted human mb-1 gene

Expression, function, and lineage infidefity


The antigen receptor on B cells (B cell receptor [BCR]) consists of two noncovalently associated modules. Immunoglobulin genes created somatically during B cell development encode the antigen-specific component of the receptor. The Igα/β heterodimer, encoded by the mb-1 and B29 genes, is necessary to escort the receptor complex to the plasma membrane. Following antigen engagement of the BCR, Igα/β nucleates signalls transduction and promotes endocytosis of bound antigen for intracellular degradation and presentation to helper T-cells. In this review, we outline the discovery of the mb-1 gene; summarize results from other laboratories on the function of Igα/β in B cells; and conclude with our recent studies; which indicate that mb-1 is not a B-line age-restricted gene as originally proposed.

Key Words

B cell receptor Igα Igβ B29 Thymus T cell Major histocompatibility complex 


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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  1. 1.Department of Microbiology, Division of Developmental and Clinical ImmunologyUniversity of Alabama at BirminghamBirmingham

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