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Immunologic Research

, Volume 22, Issue 2–3, pp 319–341 | Cite as

Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation

  • J. Brice Weinberg
Article

Abstract

Nitric oxide (NO) and prostaglandin (PG) E2 produced by NO synthase type 2 (NOS2) and cyclooxygenase type 2 (COX2), respectively, are important mediators in inflammation. There is much information regarding their roles in models of inflammation in mice and in humans with diseases such as rheumatoid arthritis (RA). A variety of stimuli including cytokines, microbial components, immune complexes, and mechanical stress can induce both NOS2 and COX2 mRNA transcription and protein synthesis and enhance inflammation. This has been demonstrated in both mice and humans. NOS2-specific inhibitors reduce inflammation in mice, and COX2-specific inhibitors reduce inflammation in mice and in humans. There is significant cross-talk between PGE2/NO and COX2/NOS2. Treatments that inhibit both NOS2 and COX2 should provide the most potent antiinflammatory effects.

Key Words

Nitric oxide Prostaglandin Monocyte macrophage inflammation rheumatoid arthritis 

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Copyright information

© Humana Press Inc 2000

Authors and Affiliations

  • J. Brice Weinberg
    • 1
  1. 1.Duke University and VA Medical CentersDurham

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