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Immunologic Research

, Volume 21, Issue 2–3, pp 159–165 | Cite as

Focal inflammation in the brain

Role in Alzheimer's disease
  • Neil R. Cooper
  • Bonnie M. Bradt
  • Stephen O'Barr
  • Jack X. Yu
Article

Abstract

We hypothesize that amyloid (Aβ) peptide-containing neuritic plaques in the brains of patients with Alzheimer's disease represent chronic inflammatory foci mediated by the actions of the complement system and proinflammatory cytokines. In support of this, in vitro studies show that the (Aβ) peptide is a potent complement activator and that such complement activation leads to the formation of covalent (Aβ)-C3 activation fragment complexes, the generation of the chemokine-like C5a complement activation peptide, and the formation of the proinflammatory C5b-9 complex in functionally active form able to insert into neuronal cell membranes. Other studies show that C5a, together with (Aβ), synergistically augments the release of proinflammatory cytokines from human monocytes. These studies, which provide in vitro support for the hypothesis, are being pursued in an animal model of Alzheimer's disease.

Key words

Alzheimer's disease Inflammation Complement C5a C5b-9 Neuritic plaques Cytokines 

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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  • Neil R. Cooper
    • 1
  • Bonnie M. Bradt
    • 1
  • Stephen O'Barr
    • 2
  • Jack X. Yu
    • 1
  1. 1.The Scripps Research InstituteLa Jolla
  2. 2.Western University of Health SciencesPomona

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