Peroral immunotheraphy with yolk antibodies for the prevention and treatment of enteric infections
- 308 Downloads
Oral administration of specific antibodies is an attractive approach to establish protective immunity against gastrointestinal pathogens in humans and animals. The increasing number of antibiotic-resistant bacteria emphasize the need to find alternatives to antibiotics. Immunotherapy can also be used against pathogens that are difficult to treat with traditional antibiotics.
Laying hens are very good producers of specific antibodies. After immunization, the specific antibodies are transported to the egg yolk from which the antibodies then can be purified. A laying hen produces more than 20 g of yolk antibodies (IgY) per year. These antibodies also have biochemical properties that make them attractive for peroral immunotherapy: They neither activate mammalian complement nor interact with mammalian Fc receptors that could mediate inflammatory response in the gastrointestinal tract. Eggs are also normal dietary components and thus there is practically no risk of toxic side effects of IgY. Yolk antibodies have been shown in several studies to prevent bacterial and viral infections.
Key WordsAntibody Chicken Egg Immunoglobulin Yolk Review
Unable to display preview. Download preview PDF.
- 2.Bartz CR, Conklin RH, Tunstall CB, Steele JH: Prevention of murine rotavirus infection with chicken egg yolk immunoglobulins. J Infect Dis 1980;242:439–441.Google Scholar
- 4.Hatta H, Tsuda K, Ozeki M, Kim M, Yamamoto T, Otake S, Hirasawa M, Katz J, Childers NK, Michalek SM: Passive immunization against dental plaque formation in humans: effect of a mouth rinse containing egg yolk antibodies (IgY) specific to Streptococcus mutans. Cancer Res 1997;31:268–274.Google Scholar
- 7.Schade R, Staak C, Hendriksen C, Erhard M, Hugl H, Koch G, Larsson A Pollmann W, Regenmortel M, Rijke E, Spielmann H, Steinbusch H, Straughan D: The production of avian (egg yolk) antibodies: IgY. ATLA 1996;24:925–934.Google Scholar
- 18.Carlander D, Kollberg H, Wejåker, PE, and Larsson A. (1999) Prevention of chronic pseudomonas aeruginosa colonisation by gargling with specific antibodies. Proceedings from the 2nd international symposium on egg nutrition and newly merging ovo-biotechnologies. CAB International, Wallingford, Oxon, UK. Book, accepted.Google Scholar
- 22.Ebina T, Tsukada K, Umezu K, Nose M, Tsuda K, Hatta H, Kim M, Yamamoto T: Gastroenteritis in suckling mice caused by human rotavirus can be prevented with egg yolk immunoglobulin (IgY) and treated with a proteinbound poly-saccharide preparation (PSK). Micro-biol Immunol 1990;34:617–629.Google Scholar