The challenge of pancreatic cancer

  • James L. Abbruzzese


  1. 1.
    Jemal A, Murray T, Samuels A. Cancer Statistics, 2003. CA Cancer J Clin 2003;53:5–26.PubMedCrossRefGoogle Scholar
  2. 2.
    Fernandez E, La Vecchia C, Porta M, Negri E, Lucchini F, Levi F. Trends in pancreatic cancer mortality in Europe. 1955–1989. Int J Cancer 1994;57:786–792.PubMedCrossRefGoogle Scholar
  3. 3.
    Williamson R. Pancreatic cancer: The greatest oncological challenge. Br Med J 1991;296:445.Google Scholar
  4. 4.
    Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549–554.PubMedCrossRefGoogle Scholar
  5. 5.
    Pellegata N, Sessa, Renault B, Bonto M, Leone B, Solicia E, Ranzani G. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res 1994;54:1556–1560.PubMedGoogle Scholar
  6. 6.
    Caldas C, Hahn S, da Costal L, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma Nat Genet 1994;8:27–32.PubMedCrossRefGoogle Scholar
  7. 7.
    Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350–353.PubMedCrossRefGoogle Scholar
  8. 8.
    Grau AM, Zhang L. Wang W, Evans DB, Abbruzzese JL, Chiao PJ. Induction of p21wafl expression and growth inhibition by transforming growth factor-β is mediated by the tumor suppressor gene DPC-4 in human pancreatic adenocarcinoma cells. Cancer Res 1997;57:3929–3934.PubMedGoogle Scholar
  9. 9.
    Sinicrope FA, Evans DB, Leach SD, et al. Bcl-2 and p53 expression in resectable pancreatic adenocarcinomas—association with clinical outcome. Clinical Cancer Res 1996;2:2015–2022.Google Scholar
  10. 10.
    Korc M, Chandrasekar B, Yamanaka Y, Friess H, Buchier M, Beger HG. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 1992;90:1352–1360.PubMedCrossRefGoogle Scholar
  11. 11.
    Yamanaka Y, Friess H, Kobrin MS, Buchler M, Kunz J, Beger HG, Korc M. Overexpression of HER2/neu oncogene in human pancreatic carcinoma. Huinan Pathology 1993;24:1127–1134.CrossRefGoogle Scholar
  12. 12.
    Wagner M, Lopez ME, Cahn M, Korc M. Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo. Gastroenterology 1998;114:798–807.PubMedCrossRefGoogle Scholar
  13. 13.
    Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res 1995;55:2007–2011.PubMedGoogle Scholar
  14. 14.
    Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary K, Chiao PJ. The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999;5:119–127.PubMedGoogle Scholar
  15. 15.
    Sonenshein GE. Rel/NF-κB transcription factors and the control of apoptosis. Seminars in Cancer Biology 1997;8:113–119.PubMedCrossRefGoogle Scholar
  16. 16.
    Wang CY, Mayo MW, Baldwin AS Jr. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996;274:784–787.PubMedCrossRefGoogle Scholar
  17. 17.
    Shi Q, Le X, Abbruzzese JL, Wang B, Mujaida N, Matsushima K, Huang S Xiong Q, Xie K. Cooperation between transcription factor AP-1 and NF-κB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. J Int Cytokine Res 1999;19:1363–1371.CrossRefGoogle Scholar
  18. 18.
    Wang W, Abbruzzese JL, Evans DB, Chiao PJ. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene 1999;18:4554–4563.PubMedCrossRefGoogle Scholar
  19. 19.
    Shi Q, Le X, Abbruzzese JL, et al. Constitutive Spl activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res 2001;61:4143–4154.PubMedGoogle Scholar

Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • James L. Abbruzzese
    • 1
  1. 1.Department of Gastrointestinal Medical OncologyThe University of Texas M.D. Anderson Cancer CenterHouston

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