Endocrine

, Volume 8, Issue 3, pp 309–315 | Cite as

Stress promotes development of ovarian cysts in rats

The possible role of sympathetic nerve activation
  • Alfonso Paredes
  • Anita Gálvez
  • Victor Leyton
  • Gabriel Aravena
  • Jenny L. Fiedler
  • Diego Bustamante
  • Hernán E. Lara
Article

Abstract

Activation of the sympathetic innervation precedes the induction of polycystic ovaries in rats given estradiol valerate (EV). The mechanism of induction by EV may thus involve both direct and neurogenic components. We tested this hypothesis using a combined cold and restraint stress to induce an increase in sympathetic tone, including that of the ovarian sympathetic nerves. Three weeks after the start of stress we found:
  1. 1.

    An increase in the content of norepinephrine (NE) in the celiac ganglion.

     
  2. 2.

    An increase in the release of NE from the ovary.

     
  3. 3.

    An unchanged NE uptake by the ovary.

     
  4. 4.

    An unchanged content of NE in the ovary.

     

The ovarian content of neuropeptide Y (NPY) (colocalized with NE) was significantly decreased. These results suggest that NE synthesis and its secretion are increased during this period and correlate with the increase in secretion of androgens and estradiol, the development of precystic follicles, and a decrease in the ovulatory rate. After 11 wk, NE release had returned to control values, whereas the ovarian NE content had risen significantly, suggesting a maintained high rate of NE synthesis. In the ovary, NPY contents, steroid secretion, morphology, and ovulation had returned to the control state. These results suggest the participation of an extraovarian factor that might act locally to control the release of NE from the ovary, and further support the hypothesis that increased sympathetic activity plays a role in the development and maintenance of ovarian cysts.

Key Words

Stress ovarian nerves steroid secretion ovarian cyst 

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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Alfonso Paredes
    • 3
  • Anita Gálvez
    • 3
  • Victor Leyton
    • 1
  • Gabriel Aravena
    • 3
  • Jenny L. Fiedler
    • 3
  • Diego Bustamante
    • 2
  • Hernán E. Lara
    • 3
  1. 1.Department of Experimental MorphologyUniversidad de ChileSantiagoChile
  2. 2.Department of Pharmacology, Faculty of MedicineUniversidad de ChileSantiagoChile
  3. 3.Laboratory of Neurobiochemistry, Department of Biochemistry and Molecular BiologyFaculty of Chemical and Pharmaceutical SciencesSantiagoChile

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