Stress promotes development of ovarian cysts in rats
- 200 Downloads
An increase in the content of norepinephrine (NE) in the celiac ganglion.
An increase in the release of NE from the ovary.
An unchanged NE uptake by the ovary.
An unchanged content of NE in the ovary.
The ovarian content of neuropeptide Y (NPY) (colocalized with NE) was significantly decreased. These results suggest that NE synthesis and its secretion are increased during this period and correlate with the increase in secretion of androgens and estradiol, the development of precystic follicles, and a decrease in the ovulatory rate. After 11 wk, NE release had returned to control values, whereas the ovarian NE content had risen significantly, suggesting a maintained high rate of NE synthesis. In the ovary, NPY contents, steroid secretion, morphology, and ovulation had returned to the control state. These results suggest the participation of an extraovarian factor that might act locally to control the release of NE from the ovary, and further support the hypothesis that increased sympathetic activity plays a role in the development and maintenance of ovarian cysts.
Key WordsStress ovarian nerves steroid secretion ovarian cyst
Unable to display preview. Download preview PDF.
- 4.Yen, S. S. C. (1991). In: Reproductive Endocrinology. Yen, S. S. C. and Jaffe, R. B. (eds.), Saunders: Philadelphia, 576–630.Google Scholar
- 12.Burden, H. W. (1985). In: Catecholamines as Hormones Regulators. Ben-Jonathan, N., Bahr, J. M., and Weiner, R. I. (eds.) Raven: New York, 261–278.Google Scholar
- 14.Mansi, J. A. and Drolet, G. (1997). Am. J. Physiol. 273, R813-R820.Google Scholar
- 17.Ojeda, S. R. and Lara, H. E. (1989). In: The Menstrual Cycle and Its Disorders. Pirke, K. M., Wuttke, W., and Scheiwerg, U. (eds.) Springer-Verlag: Berlin, 26–32.Google Scholar
- 33.Persky, H. (1962). In: Methods of Biochemical Analysis. Blick, D. (ed.) Interscience: New York, 57–60.Google Scholar
- 36.Zar, J. H. (ed.) (1984). Biostatistical Analysis. Prentice Hall: New Jersey.Google Scholar