Advertisement

Endocrine

, Volume 27, Issue 2, pp 131–135 | Cite as

Metabolic effects of melatonin on odative stress and dbetes mellitus

  • Shigeru Nishida
Article

Abstract

Melatonin, which is synthesized in the pineal gland and other tissues, has a variety of physiological, immunological, and biochemical functions. It is a direct scavenger of free radicals and has indirect antioxidant effects due to its stimulation of the expression and activity of antioxidative enzymes such as glutathione peroxidase, superoxide dismutase and catalase, and NO synthase, in mammalian cells. Melatonin also reduces serum lipid levels in mammalian species, and helps to prevent oxidative stress in diabetic subjects. long-term melatonin administration to diabetic rats reduced their hyperlipidemia and hyperinsulinemia, and restored their altered ratios of polyunsaturated fatty acid in serum and tissues. It was recently reported that melatonin enhanced insulin-receptor kinase and IRS-1 phosphorylation, suggesting the potential existence of signaling pathway cross-talk between melatonin and insulin. Because TNF-α has been shown to impair insulin action by suppressing insulin receptortyrosine kinase activity and its IRS-lyrosine phosphorylation in peripheral tissues such as skeletal muscle cells, it was speculated that melatonin might counteract TNF-α-associated insulin resistance in type 2 diabetes. This review will focus on the physiological and metabolic effects of melatonin and highlight its potential use for the treatment of cholesterol/lipid and carbohydrate disorders.

Key Words

Melatonin oxidative stress free radicals diabetes mellitus insulin polyunsaturated fatty acids cholesterol TNF-α NOS 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Reiter, R. J. (1991). Endocr. Rev. 12, 151–180.PubMedCrossRefGoogle Scholar
  2. 2.
    Reiter, R., Tang, L., Garcia, J. J., and Munoz-Hoyos, A. (1997). Life Sci. 60, 2255–2271.PubMedCrossRefGoogle Scholar
  3. 3.
    Pieri, C., Marra, M., Gaspar, R., and Damjanovich, S. (1996). Biochem. Biophys. Res. Commun. 222, 256–260.PubMedCrossRefGoogle Scholar
  4. 4.
    Hoyos, M., Guerrero, J. M., Perez-Cano, R., et al. (2000). J. Pineal Res. 28, 150–155.PubMedCrossRefGoogle Scholar
  5. 5.
    Blask, D. E., Dauchy, R. T., Sauer, L. A., and Krause, J. A. (2004). Carcinogenesis 25, 951–960.PubMedCrossRefGoogle Scholar
  6. 6.
    Blask, D. E., Sauer, L. A., Dauchy, R. T., Holowachuk, E. W., Ruhoff, M. S., and Kopff, H. S. (1999). Cancer Res. 59, 4693–4701.PubMedGoogle Scholar
  7. 7.
    Mori, N., Aoyama, H., Murase, T., and Mori, W. (1989). Acta Pathol. Jpn. 39, 613–618.PubMedGoogle Scholar
  8. 8.
    Aoyama, H., Nori, N., and Mori, W. (1988). Atherosclerosis 69, 269–272.PubMedCrossRefGoogle Scholar
  9. 9.
    Montilla, P. L., Vargas, J. F., Tunez, I. F., Munoz de Agueda, M. C., Valdelvira, M. E., and Cabrera, E. S. (1998). J. Pineal Res. 25, 94–100.PubMedCrossRefGoogle Scholar
  10. 10.
    Nishida, S., Segawa, T., Murai, I., and Nakagawa, S. (2002). J. Pineal Res. 32, 26–33.PubMedCrossRefGoogle Scholar
  11. 11.
    Garcia, J. J., Reiter, R. J., Guerrero, J. M., et al. (1997). FEBS Lett. 408, 297–300.PubMedCrossRefGoogle Scholar
  12. 12.
    Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., and Matsumoto, A. M. (1999). Endocrinology 140, 1009–1012. Erratum in Endocrinology (2002). 143, 1269.PubMedCrossRefGoogle Scholar
  13. 13.
    Wolden-Hanson, T., Mitton, D. R., McCants, R. L., et al. (2000). Endocrinology 141, 487–497.PubMedCrossRefGoogle Scholar
  14. 14.
    Barret, P., Morris, M., Choi, W. S., Ross, A., and Morgan, P. J. (1999). Biol. Signals Recept., 8, 6–14.CrossRefGoogle Scholar
  15. 15.
    Anhe, G. F., Caperuto, L. C., Pereira-Da-Silva, M., et al. (2004). J. Neurochem. 90, 559–566.PubMedCrossRefGoogle Scholar
  16. 16.
    Sener, G., Balkan, J., Cevikbas, U., Keyer-Uysal, M., and Uysal, M. (2004). J. Pineal Res. 36, 212–216.PubMedCrossRefGoogle Scholar
  17. 17.
    Darul, K. and Kruczynska, H. (2004). Acta Vet. Hung. 52, 361–367.PubMedCrossRefGoogle Scholar
  18. 18.
    Chan, T. Y. and Tang, P. L. (1995). Endocr. Res. 21, 681–696.PubMedGoogle Scholar
  19. 19.
    Muller-Wieland, D., Behnke, B., Koopmann, K., and Krone, W. (1994). Biochem. Biophys. Res. Commun. 203, 416–421.PubMedCrossRefGoogle Scholar
  20. 20.
    Baydas, G., Canatan, H., and Turkoglu, A. (2002). J. Pineal Res. 32, 225–230.PubMedCrossRefGoogle Scholar
  21. 21.
    Batcioglu, K., Karagozler, A. A., Ozturk, I. C., et al. (2005). Cancer Detect. Prev. 29, 54–58.PubMedCrossRefGoogle Scholar
  22. 22.
    Barlow-Walden, L. R., Reiter, R. J., Abe, M., et al. (1995). Neurochem. Int. 26, 495–502.Google Scholar
  23. 23.
    Cagnacci, A., Arangino, S., Renzi, A., Paoletti, A. M., Melis, G. B., Cagncci, P., and Volpe, A. (2001). Clin. Endocrinol. (Oxf.) 54, 339–346.CrossRefGoogle Scholar
  24. 24.
    Ohta, Y., Kongo-Nishimura, M., Matsura, T., Yamada, K., Kitagawa, A., and Kishikawa, T. (2004). J. Pineal Res. 36, 10–17.PubMedCrossRefGoogle Scholar
  25. 25.
    Padillo, F. J., Cruz, A., Navarrete, C., et al. (2004). Free Radic. Res. 38, 697–704.PubMedCrossRefGoogle Scholar
  26. 26.
    Antolin, I., Rodriguez, C., Sainz, R. M., et al. (1996). FASEB J. 10, 882–890.PubMedGoogle Scholar
  27. 27.
    Freeman, B. A., Young, S. L., and Crapo, J. D. (1983). J. Biol. Chem. 258, 12534–12542.PubMedGoogle Scholar
  28. 28.
    Hirose, K., Longo, D. L., Oppenheim, J. J., and Matsushima, K. (1993). FASEB J. 7, 361–368.PubMedGoogle Scholar
  29. 29.
    Moncada, S., Palmer, R. M. J., and Higgs, E. A. (1991). Pharmacol. Rev. 43, 109–142.PubMedGoogle Scholar
  30. 30.
    Szabo, C. (1996). Brain Res. Bull. 41, 131–141.PubMedGoogle Scholar
  31. 31.
    Storr, M., Koppitz, P., Sibaev, A., et al. (2002). J. Pineal Res. 33, 101–108.PubMedCrossRefGoogle Scholar
  32. 32.
    Saenz, D. A., Turjanski, A. G., Sacca, G. B., et al. (2002). J. Pineal Res. 33, 31–36.PubMedCrossRefGoogle Scholar
  33. 33.
    Crespo, E., Macias, M., Pozo, D., et al. (1999). FASEB J. 13, 1537–1546.PubMedGoogle Scholar
  34. 34.
    Rao, V. S., Santos, F. A., Silva, R. M., and Teixiera, M. G. (2002). Vascul. Pharmacol. 38, 127–130.PubMedCrossRefGoogle Scholar
  35. 35.
    Chang, H. M., Ling, E. A., Lue, J. H., Wen, C. Y., and Shieh, J. Y. (2000). Brain Res. 873, 243–251.PubMedCrossRefGoogle Scholar
  36. 36.
    Yavuz, O., Cam, M., Bukan, N., Guven, A., and Silan, F. (2003). Acta Histochem. 105, 261–266.PubMedCrossRefGoogle Scholar
  37. 37.
    Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., and Kraegen. E. W. (1991). Diabetes 40, 280–289.PubMedCrossRefGoogle Scholar
  38. 38.
    Borkman, M., Storlien, L. H., Pan, D. A., Lenkins, A. B., Chisholm, D. J., and Campbell, L. V. (1993). N. Engl. J. Med. 328, 238–244.PubMedCrossRefGoogle Scholar
  39. 39.
    Vessby, B., Tengblad, S., and Lithell, H. (1994). Diabetologia 37, 1044–1050.PubMedGoogle Scholar
  40. 40.
    Miles, P. D. G., Romeo, O. M., Higo, K., Cohen, A., Rafaat, K., and Olefsky, J. M. (1997). Diabetes 46, 1678–1683.PubMedCrossRefGoogle Scholar
  41. 41.
    Peraldi, P., Xu, M., and Spiegelman, B. M. (1997). J. Clin. Invest. 100, 1863–1869.PubMedCrossRefGoogle Scholar
  42. 42.
    Stephens, J. M., Lee, J., and Pilch, P. F. (1997). J. Biol. Chem. 272, 971–976.PubMedCrossRefGoogle Scholar
  43. 43.
    Hauner, H., Petruschke, Th., Russ, M., Röhrig, K., and Eckel, J. (1995). Diabetologia 38, 764–771.PubMedCrossRefGoogle Scholar
  44. 44.
    Hotamisligil, G. S., Shargil, N. S., and Spiegelman, B. M. (1993). Science 259, 87–91.PubMedCrossRefGoogle Scholar
  45. 45.
    Bonilla, E. and Valero, N. (2003). Neurochem. Res. 28, 681–686.PubMedCrossRefGoogle Scholar
  46. 46.
    Gitto, E., Reiter, R. J., Amodio, A., et al. (2004). J. Pineal Res. 36, 250–255.PubMedCrossRefGoogle Scholar
  47. 47.
    Bohov, P., Balaz, V., Sebokova, E., and Klimes, I. (1997). Ann. NY Acad. Sci. 827, 561–567.PubMedCrossRefGoogle Scholar
  48. 48.
    Grunfeld, C., Baird, K. L., and Kahn, C. R. (1981). Biochem. Biophys. Res. Comm. 103, 219–226.PubMedCrossRefGoogle Scholar
  49. 49.
    Ginsberg, B. H., Jabour, J., and Spector, A. A. (1982). Biochim. Biophys. Acta 690, 157–164.PubMedCrossRefGoogle Scholar
  50. 50.
    Yorek, M., Leeney, E., Dunlap, J., and Ginsberg, B. (1989). Invest. Ophthalmol. Vis. Sci. 30, 2087–2092.PubMedGoogle Scholar
  51. 51.
    Pita, M. L., Hoyos, M., Martin-Lacave, I., Osuna, C., Fernandez-Santos, J. M., and Guerrero, J. M. (2002). J. Pineal Res. 32, 179–186.PubMedCrossRefGoogle Scholar
  52. 52.
    Rodriguez, V., Mellado, C., Alvarez, E., De Diego, J. G., and Blazquez, E. (1989). J. Pineal Res. 6, 77–88.PubMedCrossRefGoogle Scholar
  53. 53.
    Nishida, S., Sato, R., Murai, I., and Nakagawa, S. (2003). J. Pineal Res. 35, 251–256.PubMedCrossRefGoogle Scholar
  54. 54.
    Lima, F. B., Machado, U. F., Bartol, I., et al. (1998). Am. J. Physiol. 275, E934-E9441.PubMedGoogle Scholar
  55. 55.
    Derlacz, R. A., Poplawski, P., Napierala, M., Jagielski, A. K., and Bryla, J. (2005). J. Pineal Res. 38, 164–169.PubMedCrossRefGoogle Scholar
  56. 56.
    Shima, T., Chun, S. J., Niijima, A., et al. (1997). Neurosci. Lett. 226, 119–122.PubMedCrossRefGoogle Scholar
  57. 57.
    Morgan, L., Arendt, J., Owens, D., et al. (1998). J. Endocrinol. 157, 443–451.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  1. 1.Department of BiochemistryNihon University School of MedicineTokyoJapan

Personalised recommendations