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Endocrine

, Volume 27, Issue 2, pp 101–110 | Cite as

Functional MT1 and MT2 melatonin receptors in mammals

  • Margarita L. DubocovichEmail author
  • Magdalena Markowska
Article

Abstract

Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of physiological processes in mammals. This review describes well-defined functional responses mediated through activation of high-affinity MT1 and MT2 proteinteoupled receptors viewed as potential targets for drug discovery. MT1 melatonin receptors modulate neuronal firing, arterial vasoconstriction, cell proliferation in cancer cells, and reproductive and metabolic functions. Ativation of MT2 melatonin receptors phase shift circadian rhythms of neuronal firing in the suprachiasmatic nucleus, inhibit dopamine release in retina, induce vasodilation and inhibition of leukocyte rolling in arterial beds, and enhance immune responses. The melatonin-mediated responses elicited by activation of MT1 and MT2 native melatonin receptors are dependent on circadian time, duration and mode of exposure to endogenous or exogenous melatonin, and functional receptor sensitivity. Together, these studies underscore the importance of carefully linking each melatonin receptor type to specific functional responses in target tissues to facilitate the design and development of novel therapeutic agent.

Key Words

MT1 and MT2 melatonin receptors MT3 site luzindole 4P-PDOT MT1 and MT2 knockout mice 

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References

  1. 1.
    Reiter, R. J. (1991). Mol. Cell Endocrinol. 79, C153-C158.PubMedCrossRefGoogle Scholar
  2. 2.
    Reiter, R. J. (1993). Experientia 49, 654–664.PubMedCrossRefGoogle Scholar
  3. 3.
    Bernard, M., Guerlotte, J., Greve, P., et al. (1999). Reprod. Nutr. Dev. 39, 325–334.PubMedGoogle Scholar
  4. 4.
    Klein, D. C., Coon, S. L., Roseboom, P. H., et al. (1997). Recent Prog. Horm. Res. 52, 307–357.PubMedGoogle Scholar
  5. 5.
    Reiter, R. J. (1980). Endocr. Rev. 1, 109–131.PubMedCrossRefGoogle Scholar
  6. 6.
    Malpaux, B., Thiery, J. C., and Chemineau, P. (1999). Reprod. Nutr. Dev. 39, 355–366.PubMedGoogle Scholar
  7. 7.
    Johnston, J. D. (2004). J. Endocrinol. 180, 351–356.PubMedCrossRefGoogle Scholar
  8. 8.
    Lincoln, G. A., Andersson, H., and Hazlerigg, D. (2003). J. Neuroendocrinol. 15, 390–397.PubMedCrossRefGoogle Scholar
  9. 9.
    Niklowitz, P., Lerchl, A., and Nieschlag, E. (1994). Biol. Reprod. 51, 714–724.PubMedCrossRefGoogle Scholar
  10. 10.
    Zawilska, J. and Nowak, J. Z. (1991). Folia Histochem. Cytobiol. 29, 3–13.PubMedGoogle Scholar
  11. 11.
    Djeridane, Y. and Touitou, Y. (2001). Exp. Eye Res. 72, 487–492.PubMedCrossRefGoogle Scholar
  12. 12.
    Bubenik, G. A. (2002). Dig. Dis. Sci. 47, 2336–2348.PubMedCrossRefGoogle Scholar
  13. 13.
    Tijmes, M., Pedraza, R., and Valladares, L. (1996). Steroids 61, 65–68.PubMedCrossRefGoogle Scholar
  14. 14.
    Carrillo-Vico, A., Calvo, J. R., Abreu, P., et al. (2004). FASEB J. 18, 537–539.PubMedGoogle Scholar
  15. 15.
    Dubocovich, M. L. (1983). Nature 306, 782–784.PubMedCrossRefGoogle Scholar
  16. 16.
    Dubocovich, M. L., Rivera-Bermudez, M. A., Gerdin, M. J., and Masana, M. I. (2003). Front. Biosci. 8, d1093-d1108.PubMedCrossRefGoogle Scholar
  17. 17.
    Dubocovich, M. I., Cardinali, D. P., Delagrange, P., et al. (2000). In: The IUPHAR compendium of receptor characterization and classification. 2nd ed. Girdlestone, D. (ed.). IUPHAR Media: London.Google Scholar
  18. 18.
    Masana, M. I. and Dubocovich, M. L. (2001). Sci. STKE 2001, PE39.Google Scholar
  19. 19.
    Reppert, S. M., Weaver, D. R., and Godson, C. (1996). Trends Pharmacol. Sci. 17, 100–102.PubMedCrossRefGoogle Scholar
  20. 20.
    Dubocovich, M. L., Masana, M. I., Iacob, S., and Sauri, D. M. (1997). Naunyn Schmiedebergs Arch. Pharmacol. 355, 365–375.PubMedCrossRefGoogle Scholar
  21. 21.
    Slaugenhaupt, S. A., Roca, A. L., Liebert, C. B., Altherr, M. R., Gusella, J. F., and Reppert, S. M. (1995). Genomics 27, 355–357.PubMedCrossRefGoogle Scholar
  22. 22.
    Song, Y., Chan, C. W., Brown, G. M., Pang, S. F., and Silverman, M. (1997). FASEB J. 11, 93–100.PubMedGoogle Scholar
  23. 23.
    Rivera-Bermudez, M. A., Masana, M. I., Brown, G. M., Earnest, D. J., and Dubocovich, M. L. (2004). Brain Res. 1002, 21–27.PubMedCrossRefGoogle Scholar
  24. 24.
    Ferguson, S. S. (2001). Pharmacol. Rev. 53, 1–24.PubMedGoogle Scholar
  25. 25.
    Nelson, C. S., Ikeda, M., Gompf, H. S., et al. (2001). Mol. Endocrinol. 15, 1306–1317.PubMedCrossRefGoogle Scholar
  26. 26.
    Mseeh, F., Gerdin, M. J., and Dubocovich, M. I. (2002). Eur. J. Pharmacol. 449, 29–38.PubMedCrossRefGoogle Scholar
  27. 27.
    Gerdin, M. J., Mseeh, F., and Dubocovich, M. L. (2003). Biochem. Pharmacol. 66, 315–320.PubMedCrossRefGoogle Scholar
  28. 28.
    Barrett, P., Conway, S., and Morgan, P. J. (2003). J. Pineal Res. 35, 221–230.PubMedCrossRefGoogle Scholar
  29. 29.
    Gerdin, M. J. and Dubocovich, M. L. (2004). J. Pineal Res. 37, 142; author reply 142.PubMedCrossRefGoogle Scholar
  30. 30.
    Gilman, A. G. (1995). Biosci. Rep. 15, 65–97.PubMedCrossRefGoogle Scholar
  31. 31.
    Vanecek, J. (1998). Physiol. Rev. 78, 687–721.PubMedGoogle Scholar
  32. 32.
    New, D. C., Tsim, S. T., and Wong, Y. H. (2003). Neurosignals 12, 59–70.PubMedCrossRefGoogle Scholar
  33. 33.
    Dubocovich, M. L. (1995). Trends Pharmacol. Sci. 16, 50–56.PubMedCrossRefGoogle Scholar
  34. 34.
    Popova, J. S. and Dubocovich, M. L. (1995). J. Neurochem. 64, 130–138.PubMedCrossRefGoogle Scholar
  35. 35.
    Nosjean, O., Ferro, M., Coge, F., et al. (2000). J. Biol. Chem. 275, 31311–31317.PubMedCrossRefGoogle Scholar
  36. 36.
    Nosjean, O., Nicolas, J. P., Klupsch, F., Delagrange, P., Canet, E., and Boutin, J. A. (2001). Biochem. Pharmacol. 61, 1369–1379.PubMedCrossRefGoogle Scholar
  37. 37.
    Mailliet, F., Ferry, G., Vella, F., Thiam, K., Delagrange, P., and Boutin, J. A. (2004). FEBS Lett. 578, 116–120.PubMedCrossRefGoogle Scholar
  38. 38.
    Roth, B. L., Sheffler, D. J., and Kroeze, W. K. (2004). Nat. Rev. Drug Discov. 3, 353–359.PubMedCrossRefGoogle Scholar
  39. 39.
    Dubocovich, M. L. (1988). J. Pharmacol. Exp. Ther. 246, 902–910.PubMedGoogle Scholar
  40. 40.
    Dubocovich, M. L., Yun, K., Al-Ghoul, W. M., Benloucif, S., and Masana, M. I. (1998). FASEB J. 12, 1211–1220.PubMedGoogle Scholar
  41. 41.
    Lotufo, C. M., Lopes, C., Dubocovich, M. L., Farsky, S. H., and Markus, R. P. (2001). Eur. J. Pharmacol. 430, 351–357.PubMedCrossRefGoogle Scholar
  42. 42.
    Gerdin, M. J., Masana, M. I., Ren, D., Miller, R. J., and Dubocovich, M. L. (2003). J. Pharmacol. Exp. Ther. 304, 931–939.PubMedCrossRefGoogle Scholar
  43. 43.
    Browning, C., Beresford, I., Fraser, N., and Giles, H. (2000). Br. J. Pharmacol. 129, 877–886.PubMedCrossRefGoogle Scholar
  44. 44.
    Soares, J. M. Jr., Masana, M. I., Ersahin, C., and Dubocovich, M. L. (2003). J. Pharmacol. Exp. Ther. 306, 694–702.PubMedCrossRefGoogle Scholar
  45. 45.
    Masana, M. I., Soares, J. M. Jr., and Dubocovich, M. L. (2005). Neuroendocrinology 81, 87–95.PubMedCrossRefGoogle Scholar
  46. 46.
    Dubocovich, M. L. and Masana, M. I. (1998). In: Biological clocks. Mechanisms and applications. Touitou, Y. (ed.). Elsevier Science: Amsterdam, pp. 289–293.Google Scholar
  47. 47.
    Sugden, D., Yeh, L. K., and Teh, M. T. (1999). Reprod. Nutr. Dev. 39, 335–344.PubMedGoogle Scholar
  48. 48.
    Descamps-Francois, C., Yous, S., Chavatte, P., et al. (2003). J. Med. Chem. 46, 1127–1129.PubMedCrossRefGoogle Scholar
  49. 49.
    Molinari, E. J., North, P. C., and Dubocovich, M. L. (1996). Eur. J. Pharmacol. 301, 159–168.PubMedCrossRefGoogle Scholar
  50. 50.
    Reppert, S. M., Weaver, D. R., Rivkees, S. A., and Stopa, E. G. (1988). Science 242, 78–81.PubMedCrossRefGoogle Scholar
  51. 51.
    Siuciak, J. A., Fang, J. M., and Dubocovich, M. L. (1990). Eur. J. Pharmacol. 180, 387–390.PubMedCrossRefGoogle Scholar
  52. 52.
    Viswanathan, M., Laitinen, J. T., and Saavedra, J. M. (1990). Proc. Natl. Acad. Sci. USA 87, 6200–6203.PubMedCrossRefGoogle Scholar
  53. 53.
    Weaver, D. R., Stehle, J. H., Stopa, E. G., and Reppert, S. M. (1993). J. Clin. Endocrinol. Metab. 76, 295–301.PubMedCrossRefGoogle Scholar
  54. 54.
    Liu, C., Weaver, D. R., Jin, X., et al. (1997). Neuron 19, 91–102.PubMedCrossRefGoogle Scholar
  55. 55.
    Peschke, E., Fauteck, J. D., Musshoff, U., Schmidt, F., Beckmann, A., and Peschke, D. (2000). J. Pineal Res. 28, 156–164.PubMedCrossRefGoogle Scholar
  56. 56.
    Torres-Farfan, C., Richter, H. G., Rojas-Garcia, P., et al. (2003). J. Clin. Endocrinol. Metab. 88, 450–458.PubMedCrossRefGoogle Scholar
  57. 57.
    Torres-Farfan, C., Richter, H. G., Germain, A. M., et al. (2004). J. Physiol. 554, 841–856.PubMedCrossRefGoogle Scholar
  58. 58.
    Fujieda, H., Scher, J., Hamadanizadeh, S. A., Wankiewicz, E., Pang, S. F., and Brown, G. M. (2000). Vis. Neurosci. 17, 63–70.PubMedCrossRefGoogle Scholar
  59. 59.
    Scher, J., Wankiewicz, E., Brown, G. M., and Fujieda, H. (2002). Invest. Ophthalmol. Vis. Sci. 43, 889–897.PubMedGoogle Scholar
  60. 60.
    Meyer, P., Pache, M., Loeffler, K. U., et al. (2002). Br. J. Ophthalmol. 86, 1053–1057.PubMedCrossRefGoogle Scholar
  61. 61.
    Savaskan, E., Wirz-Justice, A., Olivieri, G., et al. (2002). J. Histochem. Cytochem. 50, 519–526.PubMedGoogle Scholar
  62. 62.
    Clemens, J. W., Jarzynka, M. J., and Witt-Enderby, P. A. (2001). Life Sci. 69, 27–35.PubMedCrossRefGoogle Scholar
  63. 63.
    Carrillo-Vico, A., Garcia-Perganeda, A., Naji, L., Calvo, J. R., Romero, M. P., and Guerrero, J. M. (2003). Cell Mol. Life Sci. 60, 2272–2278.PubMedCrossRefGoogle Scholar
  64. 64.
    Al-Ghoul, W. M., Herman, M. D., and Dubocovich, M. L. (1998). Neuroreport 9, 4063–4068.PubMedCrossRefGoogle Scholar
  65. 65.
    Moore, R. Y. (1995). Ciba Found. Symp. 183, 88–99; discussion 100–106.PubMedGoogle Scholar
  66. 66.
    Gillette, M. U. and Mitchell, J. W. (2002). Cell Tissue Res. 309, 99–107.PubMedCrossRefGoogle Scholar
  67. 67.
    Fujieda, H., Hamadanizadeh, S. A., Wankiewicz, E., Pang, S. F., and Brown, G. M. (1999). Neuroscience 93, 793–799.PubMedCrossRefGoogle Scholar
  68. 68.
    Reppert, S. M. and Weaver, D. R. (2001). Annu. Rev. Physiol. 63, 647–676.PubMedCrossRefGoogle Scholar
  69. 69.
    Axelrod, J. and Wurtman, R. J. (1968). Adv. Pharmacol. 6, 157–166.PubMedCrossRefGoogle Scholar
  70. 70.
    Moore, R. Y. (1996). Behav. Brain Res. 73, 125–130.PubMedCrossRefGoogle Scholar
  71. 71.
    Hunt, A. E., Al-Ghoul, W. M., Gillette, M. U., and Dubocovich, M. L. (2001). Am. J. Physiol. Cell Physiol. 280, C110-C118.PubMedGoogle Scholar
  72. 72.
    Hurst, W. J., Earnest, D., and Gillette, M. U. (2002). Biochem. Biophys. Res. Commun. 292, 20–30.PubMedCrossRefGoogle Scholar
  73. 73.
    Poirel, V. J., Masson-Pevet, M., Pevet, P., and Gauer, F. (2002). Brain Res. 946, 64–71.PubMedCrossRefGoogle Scholar
  74. 74.
    von Gall, C., Weaver, D. R., Kock, M., Korf, H. W., and Stehle, J. H. (2000). Neuroreport 11, 1803–1807.CrossRefGoogle Scholar
  75. 75.
    Jin, X., von Gall, C., Pieschl, R. L., et al. (2003). Mol. Cell Biol. 23, 1054–1060.PubMedCrossRefGoogle Scholar
  76. 76.
    Mason, R. and Brooks, A. (1988). Neurosci. Lett. 95, 296–301.PubMedCrossRefGoogle Scholar
  77. 77.
    Shibata, S., Cassone, V. M., and Moore, R. Y. (1989). Neurosci. Lett. 97, 140–144.PubMedCrossRefGoogle Scholar
  78. 78.
    Jiang, Z. G., Nelson, C. S., and Allen, C. N. (1995). Brain Res. 687, 125–132.PubMedCrossRefGoogle Scholar
  79. 79.
    Nelson, C. S., Marino, J. L., and Allen, C. N. (1996). Neuroreport 7, 717–720.PubMedCrossRefGoogle Scholar
  80. 80.
    Stehle, J., Vanecek, J., and Vollrath, L. (1989). J. Neural Transm. 78, 173–177.PubMedCrossRefGoogle Scholar
  81. 81.
    Zhdanova, I. V. (2005). Sleep Med. Rev. 9, 51–65.PubMedCrossRefGoogle Scholar
  82. 82.
    Benloucif, S. and Dubocovich, M. L. (1996). J. Biol. Rhythms 11, 113–125.PubMedCrossRefGoogle Scholar
  83. 83.
    McArthur, A. J., Hunt, A. E., and Gillette, M. U. (1997). Endocrinology 138, 627–634.PubMedCrossRefGoogle Scholar
  84. 84.
    Gerdin, M. J., Masana, M. I., and Dubocovich, M. L. (2004). Biochem. Pharmacol. 67, 2023–2030.PubMedCrossRefGoogle Scholar
  85. 85.
    Gerdin, M. J., Masana, M. I., Rivera-Bermudez, M. A., et al. (2004). FASEB J. 18, 1646–1656.PubMedCrossRefGoogle Scholar
  86. 86.
    Armstrong, S. M. and Redman, J. R. (1993). In: Melatonin: biosynthesis, physiological effects, and clinical applications. Yu, H. S. and Reiter, R. J. (eds.). CRC Press, pp. 187–223.Google Scholar
  87. 87.
    Wirz-Justice, A., Werth, E., Renz, C., Muller, S., and Krauchi, K. (2002). J. Pineal Res. 32, 1–5.PubMedCrossRefGoogle Scholar
  88. 88.
    von Gall, C., Lewy, A., Schomerus, C., et al. (2000). Eur. J. Neurosci. 12, 964–972.CrossRefGoogle Scholar
  89. 89.
    Dubocovich, M. L., Hudson, R. L., Sumaya, I. C., Masana, M. I., and Manna, E. (2005). J. Pineal Res. 39, 113–120.PubMedCrossRefGoogle Scholar
  90. 90.
    Hudson, R. L., Lee, J.I., and Dubocovich, M. L. (2004). FASEB J. 18, Abstract 639.8.Google Scholar
  91. 91.
    Arendt, J. and Skene, D. J. (2005). Sleep Med. Rev. 9, 25–39.PubMedCrossRefGoogle Scholar
  92. 92.
    Tamarkin, L., Baird, C. J., and Almeida, O. F. (1985). Science 227, 714–720.PubMedCrossRefGoogle Scholar
  93. 93.
    Malpaux, B., Migaud, M., Tricoire, H., and Chemineau, P. (2001). J. Biol. Rhythms 16, 336–347.PubMedCrossRefGoogle Scholar
  94. 94.
    Roy, D., Angelini, N. L., Fujieda, H., Brown, G. M., and Belsham, D. D. (2001). Endocrinology 142, 4711–4720.PubMedCrossRefGoogle Scholar
  95. 95.
    Frungieri, M. B., Mayerhofer, A., Zitta, K., Pignataro, O. P., Calandra, R. S., and Gonzalez-Calvar, S. I. (2005). Endocrinology 146, 1541–1552.PubMedCrossRefGoogle Scholar
  96. 96.
    Vanecek, J. and Vollrath, L. (1990). Endocrinology 126, 1509–1513.PubMedGoogle Scholar
  97. 97.
    Vanecek, J. and Klein, D. C. (1995). Am. J. Physiol. 269, E85-E90.PubMedGoogle Scholar
  98. 98.
    Martin, J. E., McKellar, S., and Klein, D. C. (1980). Neuroendocrinology 31, 13–17.PubMedGoogle Scholar
  99. 99.
    Johnston, J. D., Messager, S., Barrett, P., and Hazlerigg, D. G. (2003). J. Neuroendocrinol. 15, 405–408.PubMedCrossRefGoogle Scholar
  100. 100.
    Johnston, J. D., Messager, S., Ebling, F. J., Williams, L. M., Barrett, P., and Hazlerigg, D. G. (2003). Proc. Natl. Acad. Sci. USA 100, 2831–2835.PubMedCrossRefGoogle Scholar
  101. 101.
    Balik, A., Kretschmannova, K., Mazna, P., Svobodova, I., and Zemkova, H. (2004). Physiol. Res. 53(Suppl. 1), S153-S166.PubMedGoogle Scholar
  102. 102.
    Brzezinski, A., Seibel, M. M., Lynch, H. J., Deng, M. H., and Wurtman, R. J. (1987). J. Clin. Endocrinol. Metab. 64, 865–867.PubMedGoogle Scholar
  103. 103.
    Ronnberg, L., Kauppila, A., Leppaluoto, J., Martikainen, H., and Vakkuri, O. (1990). J. Clin. Endocrinol. Metab. 71, 492–496.PubMedGoogle Scholar
  104. 104.
    Woo, M. M., Tai, C. J., Kang, S. K., Nathwani, P. S., Pang, S. F., and Leung, P. C. (2001). J. Clin. Endocrinol. Metab. 86, 4789–4797.PubMedCrossRefGoogle Scholar
  105. 105.
    Niles, L. P., Wang, J., Shen, L., Lobb, D. K., and Younglai, E. V. (1999). Mol. Cell Endocrinol. 156, 107–110.PubMedCrossRefGoogle Scholar
  106. 106.
    Schaeffer, H. J. and Sirotkin, A. V. (1995). Adv. Exp. Med. Biol. 395, 547–548.PubMedGoogle Scholar
  107. 107.
    von Gall, C., Garabette, M. L., Kell, C. A., et al. (2002). Nat. Neurosci. 5, 234–238.CrossRefGoogle Scholar
  108. 108.
    Weitzman, E. D., Fukushima, D., Nogeire, C., Roffwarg, H., Gallagher, T. F., and Hellman, L. (1971). J. Clin. Endocrinol. Metab. 33, 14–22.PubMedCrossRefGoogle Scholar
  109. 109.
    Demas, G. E., Polacek, K. M., Durazzo, A., and Jasnow, A. M. (2004). Horm. Behav. 46, 582–591.PubMedCrossRefGoogle Scholar
  110. 110.
    Barrenetxe, J., Delagrange, P., and Martinez, J. A. (2004). J. Physiol. Biochem. 60, 61–72.PubMedCrossRefGoogle Scholar
  111. 111.
    Peschke, E., Muhlbauer, E., Musshoff, U., Csernus, V. J., Chankiewitz, E., and Peschke, D. (2002). J. Pineal Res. 33, 63–71.PubMedCrossRefGoogle Scholar
  112. 112.
    Kemp, D. M., Ubeda, M., and Habener, J.F. (2002). Mol. Cell Endocrinol. 191, 157–166.PubMedCrossRefGoogle Scholar
  113. 113.
    Zalatan, F., Krause, J. A., and Blask, D. E. (2001). Endocrinology 142, 3783–3790.PubMedCrossRefGoogle Scholar
  114. 114.
    Alonso-Vale, M. I., Andreotti, S., Peres, S. B., et al. (2005). Am. J. Physiol. Endocrinol. Metab. 288, E805-E812.PubMedCrossRefGoogle Scholar
  115. 115.
    Masana, M. I., Doolen, S., Ersahin, C., et al. (2002). J. Pharmacol. Exp. Ther. 302, 1295–1302.PubMedCrossRefGoogle Scholar
  116. 116.
    Savaskan, E., Olivieri, G., Brydon, L., et al. (2001). Neurosci. Lett. 308, 9–12.PubMedCrossRefGoogle Scholar
  117. 117.
    Krause, D. N., Barrios, V. E., and Duckles, S. P. (1995). Eur. J. Pharmacol. 276, 207–213.PubMedCrossRefGoogle Scholar
  118. 118.
    Geary, G. G., Duckles, S. P., and Krause, D. N. (1998). Br. J. Pharmacol. 123, 1533–1540.PubMedCrossRefGoogle Scholar
  119. 119.
    Nelson, M. T. and Quayle, J. M. (1995). Am. J. Physiol. 268, C799-C822.PubMedGoogle Scholar
  120. 120.
    Mahle, C. D., Goggins, G. D., Agarwal, P., Ryan, E., and Watson, A. J. (1997). J. Biol. Rhythms 12, 690–696.PubMedCrossRefGoogle Scholar
  121. 121.
    Regrigny, O., Delagrange, P., Scalbert, E., Atkinson, J., and Lartaud-Idjouadiene, I. (1998). Am. J. Physiol. 275, H139-H144.PubMedGoogle Scholar
  122. 122.
    Doolen, S., Krause, D. N., Dubocovich, M. L., and Duckles, S. P. (1998). Eur. J. Pharmacol. 345, 67–69.PubMedCrossRefGoogle Scholar
  123. 123.
    Krauchi, K., Cajochen, C., Werth, E., and Wirz-Justice, A. (2000). Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R741-R748.PubMedGoogle Scholar
  124. 124.
    Pintor, J., Pelaez, T., Hoyle, C. H., and Peral, A. (2003). Br. J. Pharmacol. 138, 831–836.PubMedCrossRefGoogle Scholar
  125. 125.
    Csaba, G. and Barath, P. (1975). Endocrinol. Exp. 9, 59–67.PubMedGoogle Scholar
  126. 126.
    Nelson, R. J. and Drazen, D. L. (2000). Ann. NY Acad. Sci. 917, 404–415.PubMedCrossRefGoogle Scholar
  127. 127.
    Lopes, C., deLyra, J. L., Markus, R. P., and Mariano, M. (1997). J. Pineal Res. 23, 72–78.PubMedCrossRefGoogle Scholar
  128. 128.
    Maestroni, G. J. (1999). Adv. Exp. Med. Biol. 460, 395–405.PubMedGoogle Scholar
  129. 129.
    Guerrero, J. M. and Reiter, R. J. (2002). Curr. Top. Med. Chem. 2, 167–179.PubMedCrossRefGoogle Scholar
  130. 130.
    Skwarlo-Sonta, K., Majewski, P., Markowska, M., Oblap, R., and Olszanska, B. (2003). Can. J. Physiol. Pharmacol. 81, 342–349.PubMedCrossRefGoogle Scholar
  131. 131.
    Drazen, D. L., Bilu, D., Bilbo, S. D., and Nelson, R. J. (2001). Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R1476-R1482.PubMedGoogle Scholar
  132. 132.
    Drazen, D. L. and Nelson, R. J. (2001). Neuroendocrinology 74, 178–184.PubMedCrossRefGoogle Scholar
  133. 133.
    Carrillo-Vico, A., Garcia-Maurino, S., Calvo, J. R., and Guerrero, J. M. (2003). FASEB J. 17, 755–757.PubMedGoogle Scholar
  134. 134.
    Carrillo-Vico, A., Lardone, P. J., Fernandez-Santos, J. M., et al. (2005). J. Clin. Endocrinol. Metab. 90, 992–1000.PubMedCrossRefGoogle Scholar
  135. 135.
    Pawlikowski, M., Winczyk, K., and Karasek, M. (2002). NeuroEndocrinol. Lett. 23(Suppl. 1), 24–29.PubMedGoogle Scholar
  136. 136.
    Sanchez-Barcelo, E. J., Cos, S., Fernandez, R., and Mediavilla, M. D. (2003). Endocr. Relat. Cancer 10, 153–159.PubMedCrossRefGoogle Scholar
  137. 137.
    Shiu, S. Y., Li, L., Xu, J. N., Pang, C. S., Wong, J. T., and Pang, S. F. (1999). J. Pineal Res. 27, 183–192.PubMedCrossRefGoogle Scholar
  138. 138.
    Reiter, R. J., Tan, D. X., Manchester, L. C., and Qi, W. (2001). Cell Biochem. Biophys. 34, 237–256.PubMedCrossRefGoogle Scholar
  139. 139.
    Xi, S. C., Siu, S. W., Fong, S. W., and Shiu, S. Y. (2001). Prostate 46, 52–61.PubMedCrossRefGoogle Scholar
  140. 140.
    Ram, P. T., Dai, J., Yuan, L., et al. (2002). Cancer Lett. 179, 141–150.PubMedCrossRefGoogle Scholar
  141. 141.
    Karasek, M., Carrillo-Vico, A., Guerrero, J. M., Winczyk, K., and Pawlikowski, M. (2002). NeuroEndocrinol. Lett. 23(Suppl. 1), 55–60.PubMedGoogle Scholar
  142. 142.
    Shiu, S. Y., Xi, S. C., Xu, J. N., et al. (2000). Life Sci. 67, 2059–2074.PubMedCrossRefGoogle Scholar
  143. 143.
    Aust, S., Thalhammer, T., Humpeler, S., et al. (2004). J. Pineal Res. 36, 43–48.PubMedCrossRefGoogle Scholar
  144. 144.
    Dillon, D. C., Easley, S. E., Asch, B. B., et al. (2002). Am. J. Clin. Pathol. 118, 451–458.PubMedCrossRefGoogle Scholar
  145. 145.
    Kanishi, Y., Kobayashi, Y., Noda, S., Ishizuka, B., and Saito, K. (2000). J. Pineal Res. 28, 227–233.PubMedCrossRefGoogle Scholar
  146. 146.
    Bordt, S. L., McKeon, R. M., Li, P. K., Witt-Enderby, P. A., and Melan, M. A. (2001). Biochim. Biophys. Acta 1499, 257–264.PubMedCrossRefGoogle Scholar
  147. 147.
    Blask, D. E., Sauer, L. A., and Dauchy, R. T. (2002). Curr. Top. Med. Chem. 2, 113–132.PubMedCrossRefGoogle Scholar
  148. 148.
    Kadekaro, A. L., Andrade, L. N., Floeter-Winter, L. M., et al. (2004). J. Pineal Res. 36, 204–211.PubMedCrossRefGoogle Scholar
  149. 149.
    Collins, A., Yuan, L., Kiefer, T. L., Cheng, Q., Lai, L., and Hill, S. M. (2003). Cancer Lett. 189, 49–57.PubMedCrossRefGoogle Scholar
  150. 150.
    Yuan, L., Collins, A. R., Dai, J., Dubocovich, M. L., and Hill, S. M. (2002). Mol. Cell Endocrinol. 192, 147–156.PubMedCrossRefGoogle Scholar
  151. 151.
    Witt-Enderby, P. A., Masana, M. I., and Dubocovich, M. L. (1998). Endocrinology 139, 3064–3071.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  1. 1.Department of Molecular Pharmacology & Biological Chemistry, Department of Psychiatry & Behavioral SciencesNorthwestern University Feinberg School of Medicine Center for Drug Discovery and Chemical Biology Northwestern UniversityChicago

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