Advertisement

Endocrine

, Volume 25, Issue 2, pp 117–119 | Cite as

α-Zearalanol, a phytoestrogen for cardiovascular therapy

  • Shunling Dai
  • Jinhong Duan
  • Yuan Lu
  • Jinxuan Cheng
  • Jun Ren
  • Wenhui Deng
  • Yiyong Wu
Original Articles

Abstract

Estrogen replacement therapy (ERT) is one of the most challenging issues women and their physicians have to face. Clinical and epidemiological studies have provided conflicting data regarding the cardiovascular benefit versus risk in women using ERT. Although ERT may improve several risk factors of coronary heart disease such as favorable changes in lipid profile, an associated increased incidence of uterine and breast tumors has jeopardized the clinical use of ERT. We reported here that the phytoestrogen α-zearalanol is effective against atherosclerotic development without overt growth-promoting effects in the uterus compared to estrogen. These results suggest clinical potential of this phytoestrogen as a “safe estrogen” with less risk of tumorogenesis.

Key Words

Phytoestrogen estrogen cardiovascular atherosclerosis uterine growth 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wenger, N. K. (2004). Circulation 109, 558–560.PubMedCrossRefGoogle Scholar
  2. 2.
    Subbiah, M. T. (2002). Braz. J. Med. Biol. Res. 35, 271–276.PubMedCrossRefGoogle Scholar
  3. 3.
    Mosca, L., Collins, P., Herrington, D. M., et al. (2001). Circulation 104, 499–503.PubMedGoogle Scholar
  4. 4.
    Mosca, L., Appel, L. J., Benjamin, E. J., et al. (2004). Circulation 109, 672–693.PubMedCrossRefGoogle Scholar
  5. 5.
    Knight, D. C. and Eden, J. A. (1995). Maturitas 22, 167–175.PubMedCrossRefGoogle Scholar
  6. 6.
    Dai, S., Duan, J., Lu, Y., et al. (2004). Endocrine 25, xxx-xxx.Google Scholar
  7. 7.
    Stob, M., Boldwin, R. S., Tuite, J., Andrews, F. N., and Gitlette, K. C. (1962). Nature 196, 1318.PubMedCrossRefGoogle Scholar
  8. 8.
    Li, J. L., Zhu, T. X., Zhang, H., et al. (1980). Acta Agricul. Universitatis Pekinensis 1, 13–27.Google Scholar
  9. 9.
    Fu, F. Y. (1991). Acta Agricul. Universitatis Pekinensis 17, 117–118.Google Scholar
  10. 10.
    Dai, S., Duan, J., Lu, Y., et al. (2002). J. Mol. Cell. Cardiol. 34, A3.Google Scholar
  11. 11.
    Bhavnani, B. R. (2003). J. Steroid Biochem. Mol. Biol. 85, 473–482.PubMedCrossRefGoogle Scholar
  12. 12.
    Gajecki, M. (2002). Pol. J. Vet. Sci. 5, 117–122.PubMedGoogle Scholar
  13. 13.
    Young, L. G. and King, G. J. (1986). J. Anim. Sci. 63, 1191–1196.PubMedGoogle Scholar
  14. 14.
    Altavilla, D., Saitta, A., Galeano, M., et al. (2001). Lab Invest. 81, 125–132.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Shunling Dai
    • 3
  • Jinhong Duan
    • 3
  • Yuan Lu
    • 3
  • Jinxuan Cheng
    • 3
  • Jun Ren
    • 1
  • Wenhui Deng
    • 2
  • Yiyong Wu
    • 2
  1. 1.Center for Cardiovascular Research and Alternative MedicineUniversity of WyomingLaramieUSA
  2. 2.Department of Obstetric and GynecologyBeijing HospitalBeijingP. R. China
  3. 3.Institute of Basic Medical Sciences, Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP. R. China

Personalised recommendations