Angiotensin-(1–7) in normal and preeclamptic pregnancy
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Angiotensin-(1–7) (Ang-[1–7]) is a bioactive component of the renin-angiotensin system, which has depressor, vasodilatory, and antihypertensive actions. In normal pregnancy, we questioned whether the known rise in plasma angiotensin II (Ang II) is counterbalanced by an increase in plasma Ang-(1–7) and whether Ang-(1–7) levels are decreased in preeclampsia and may thus be a factor involved in the development of hypertension. Nulliparous preeclamptic subjects, third-trimester normotensive pregnant subjects, and a nonpregnant group were enrolled (n=15/group). Preeclamptic subjects had no previous history of hypertension or renal, connective-tissue, or metabolic disease, but at the time of delivery had significant hypertension (159±3/98±3 mmHg) and ≥3+ proteinuria. Plasma Ang-(1–7) was increased by 51% in normal pregnancy (p<0.05). Plasma Ang I, Ang II, and renin activity were also significantly elevated in normal pregnancy. In preeclamptic subjects, Ang-(1–7) was significantly decreased (p<0.01) compared with normal pregnant subjects. All other components of the renin-angiotensin-aldosterone system, except serum angiotensin-converting enzyme, were reduced in preeclamptic subjects compared with normal pregnant subjects; only plasma Ang II remained elevated in preeclamptic compared with nonpregnant subjects. These studies demonstrate, for the first time, increased plasma Ang-(1–7) in normal pregnant subjects compared with nonpregnant subjects and decreased Ang-(1–7) in preeclamptic subjects compared with normal pregnant subjects. In preeclampsia the decreased plasma Ang-(1–7) in the presence of elevated Ang II is consistent with the development of hypertension.
Key WordsAngiotensin peptides angiotensin-(1–7) angiotensin II pregnancy preeclampsia vasoactive peptides
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- 1.The Working Group on High Blood Pressure in Pregnancy. National High Blood Pressure Education Program (NHPEP). (1991). Publication no. 91-3029. United States Department of Health and Human Services, Bethesda, MD.Google Scholar
- 3.August, P. and Sealey, J. E. (1990). In: Hypertension pathophysiology, diagnosis, and management. Laragh, J. H. and Brenner, B. M. (eds.). Raven: New York.Google Scholar
- 6.Elebute, O. A. and Mills, I. H. (1976). In: Hypertension in pregnancy. Lindheimer, K. Z. (ed.). Wiley: New York.Google Scholar
- 9.Valdes, G., Corthorn, J., Oyarzun, E., Berrios, C., Foradori, A., Germain, A. M., and Villarroel, L. (1998). Prenat. Neonat. Med. 3, 474–481.Google Scholar
- 10.Odar-Cederlöf, I., Floberg, J., Theodorsson, E., and Fried, S. (1997). Hypertens. Pregnancy 16, 19–34.Google Scholar
- 23.Pipkin, F. B. and Baker, P. N. (1997). Hypertension 30, 1247–1252.Google Scholar