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Endocrine

, Volume 18, Issue 2, pp 129–133 | Cite as

Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for graves’ disease

  • Robertas Bunevicius
  • Neli Jakubonien
  • Renaldas Jurkevicius
  • Jurate Cernicat
  • Liudvikas Lašas
  • Arthur J. PrangeJr.
Article

Abstract

It was recently demonstrated that treatment with levorotatory thyroxine (T4) plus triodotthyronine (T3) compared with treatment with T4 alone improves psychologic functioning in hypothyroid patients with thyroid cancer or autoimmune thyroiditis. In the present double-blind crossover study, we again compared the effects of combined thyroid replacement vs monotherapy on psychologic function, endocrine function, cardiovascular function, and body composition. The patients were women who were hypothyroid after thyroidectomy for Graves’ disease. The substitution of 10 µg of T3 for 50 µg of T4 caused a statistically significant decrease in free T4 concentration but no significant change in T3 or thyroid-stimulating hormone concentration. Symptoms of hypothyroidism and of hyperthyroidism tended to decrease on a standard symptom scale after combined treatment. With combined hormone replacement, mental state tended to improve on some mood scales but not on cognitive tests. We found alterations in left ventricular diastolic function but no change in body composition after the combined treatment regimen. These preliminary findings in a small group of patients with Graves’ disease are consistent with earlier findings that thyroid replacement with T4-T3 combination improves mental functioning.

Key Words

Graves’ disease hypothyroidism triidothyronine levorotatory thyroxine 

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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Robertas Bunevicius
    • 1
  • Neli Jakubonien
    • 2
  • Renaldas Jurkevicius
    • 3
  • Jurate Cernicat
    • 1
  • Liudvikas Lašas
    • 1
  • Arthur J. PrangeJr.
    • 4
  1. 1.Institute of EndocrinologyClinic of the Kaunas Medical UniversityKaunasLithuania
  2. 2.Department of EndocrinologyClinic of the Kaunas Medical UniversityKaunasLithuania
  3. 3.Department of CardiologyClinic of the Kaunas Medical UniversityKaunasLithuania
  4. 4.Department of Psychiatry, CB# 7160University of North Carolina School of MedicineChapel Hill

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