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Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infaractions

Implications for Therapy

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Abstract

Muscle infaction is a rare complication in patients with diabetes mellitus, probably because of the rich vascular supply of this tissue. We describe a patient with type 1 diabetes who had infarction of the muscles in her right thigh. We report, for the first time, that the patient, in addition to an advanced microvascular disease in the muscle, had increased plasma total homocysteine levels and increased platelet aggregation. These pathologies might have a synergistic effect on the development of this rare complication and should be treated aggrssively to prevent further episodes.

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References

  1. 1.

    Angervall, L., and Stener, B. (1965). Diabetologia 1, 39–42.

  2. 2.

    Scully, R. E., Mark, E. J., McNeely, W. F., Ebeling, S. H., Phillips, L. D. (1997). N. Engl., J. Med. 337, 839–845.

  3. 3.

    Umpierrez, G. E., Stiles, R. G., Kleinbart, J., Krendel, D. A., Watts, N. B. (1996). Am. J. Med. 101, 245–250.

  4. 4.

    Khoury, N. J., El-Khoury, G. Y., Kathol, M. H. (1997). Skel. Radiol. 26, 122–127.

  5. 5.

    Reich, S., Weiner, S. N., Chester, S. (1985). Clini. Nucl. Med. 10, 876–879.

  6. 6.

    Martin, S. C., Hilton, A. C., Bartlett, W. A., Jones, A. F. (1998). Biomed Chromatol 12, 1–2.

  7. 7.

    Nunez-Hoyo, M., Gardner, C. L., Motta, A. O., Ashmead, J. W. (1993). J. Comput. Assist. Tomogr. 17, 986–988.

  8. 8.

    Bjornskov, E. K., Carry, M. R., Katz, F. H., Lefkowitz, J., Ringel, S. P. (1995). Neuromsc. Disord. 5, 39–45.

  9. 9.

    Fonseca, V. A., Stone, A., Munshi, M., Baliga, B. S., Aljada, A., Thusu, K., and Dandona, P. (1997). Sourth. Med. J. 90, 903–906.

  10. 10.

    Munshi, M. N., Stone, A., Fink, L., Fonseca, V. (1996). Metab. Clini. and Exp. 45, 133–135.

  11. 11.

    Araki, A., Sako, Y., Ito, H. (1993). Atherosclerosis 103, 149–57.

  12. 12.

    Hoffman, M. A., Kohl, B., Zumbach, M. S., Borcea, V., Bierhaus, A., Henkels, A., Amiral, J., Fiehn, W., Ziegler, R., Wahl, P., and Nawroth, P. P. (1997). Diabetes Care 20, 1880–1885.

  13. 13.

    Okada, E., Oida, K., Tada, H., Asazuma, K., Eguchi, K., Tohda, G., Kosaka, S., Takahashi, S., Miyamori, I. (1999). Diabetes Care 22, 484–490.

  14. 14.

    Welch, G. N. and Loscalzo, J. (1998). N. Engl. J. Med. 338, 1042–1050.

  15. 15.

    Tschoepe, D., Roesen, P., Schwippet, B., Gries, F. A. (1993). Semin. Thromb. Hemost. 19, 122–128.

  16. 16.

    Glasman, A. B. (1993). Ann. Clin. Lab. Sci. 23, 47–50.

  17. 17.

    Kwaan, H. C. (1996). Diabetes 45, 109-S110.

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Correspondence to Joseph Levy.

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Rajkumar, V., Ragatzki, P., Sima, A. et al. Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infaractions. Endocr 11, 57–60 (1999). https://doi.org/10.1385/ENDO:11:1:57

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Key Words

  • Diabetes
  • homocysteine
  • muscle infarction
  • folic acid
  • aspirin