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Endocrine

, Volume 11, Issue 1, pp 1–11 | Cite as

DHEA and the skeleton (through the ages)

  • Catherine M. GordonEmail author
  • Julie Glowacki
  • Meryl S. LeBoff
Review

Abstract

Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, are the most abundant steroids in the human circulation, although their exact biological significance is not completely understood. DHEA(S) levels are high in fetal life, decrease after birth, and show a marked pubertal increase to a maximal level during young adulthood. In healthy adults, DHEAS levels decline to 10–20% of peak levels by age 70 yr. This review summarizes information concerning the role of DHEA in skeletal physiology, including modulation of the skeletal insulin-like growth factor regulatory system, and its effects on secretion of proresorptive cytokines. The pattern of secretion of DHEA throughout the life cycle is discussed, as well as its potential usefulness in specific disease states as an agent with anabolic and antiosteolyic effects on bone.

Key Words

DHEA osteoporosis aging insulin-like growth factors cytokines 
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Copyright information

© Humana Press Inc 1999

Authors and Affiliations

  • Catherine M. Gordon
    • 1
    Email author
  • Julie Glowacki
    • 2
  • Meryl S. LeBoff
    • 3
  1. 1.Divisions of Adolescent/Young Adult Medicine and EndocrinologyChildren's HospitalBoston
  2. 2.Department of Orthopedic Surgery, Brigham and Women's HospitalHarvard Medical SchoolBoston
  3. 3.Endocrine/Hypertension Division, Department of Medicine, Brigham and Women's HospitalHarvard Medical SchoolBoston

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