Cardiovascular Toxicology

, Volume 5, Issue 4, pp 345–354 | Cite as

Cardiovascular toxicities upon managanese exposure

  • Yueming Jiang
  • Wei Zheng


Manganese (Mn)-induced Parkinsonism has been well documented; however, little attention has been devoted to Mn-induced cardiovascular dysfunction. This review summarizes literature data from both animal and human studies on Mn’s effect on cardiovascular function. Clinical and epidemiological evidence suggests that the incidence of abnormal electrocardiogram (ECG) is significantly higher in Mn-exposed workers than that in the control subjects. The main types of abnormal ECG include sinus tachycardia, sinus bradycardia, sinus arrhythmia, sinister megacardia, and ST-T changes. The accelerated heart-beat and shortened P-R interval appear to be more prominent in fermale exposed workers than in their male counterparts. Mn-exposed workers display a mean diastolic blood pressure that is significantly lower than that of the control subjects, especially in the young and female exposed workers. Animal studies indicate that Mn is capable of quickly accumulating in heart tissue, resulting in acute or sub-acute cardiovascular disorders, such as a cute cardio-depression and hypotension. These toxic outcomes appear to be associated with Mn-induced mitochondrial damage and interaction with the calcium channel in the cardiovascular system.

Key Words

Managanese occupational exposure cardiovascular toxicity ECG hypotension vasodilatation 


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Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  1. 1.Department of Occupational Health and ToxicologyGuangxi Medical UniversityGuangxiPRC
  2. 2.School of Health SciencesPurdue UniversityWest Lafayette

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