Cardiovascular Toxicology

, Volume 3, Issue 3, pp 183–190

Apoptosis in heart failure and the senescent heart

  • Oliver Y. Bernecker
  • Fawzia Huq
  • E. Kevin Heist
  • Bruno K. Podesser
  • Roger J. Hajjar
Article

Abstract

The progressive loss of cardiac myocytes by apoptotic cell death has been discussed as an important pathogenic component in the failing myocardium as well in the aging heart. The degree to which apoptosis contributes to myocyte loss in these conditions, however, is a controversial issue. This review focuses on the regulation of apoptosis, evidence implicating apoptosis as a mechanism for the progression and development of heart failure, the role of apoptotic death in senescent cardiac dysfunction, as well as on the problems of detection of apoptosis.

Key words

Apoptosis cell death aging myocardium 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Oliver Y. Bernecker
    • 1
  • Fawzia Huq
    • 1
  • E. Kevin Heist
    • 1
  • Bruno K. Podesser
    • 2
  • Roger J. Hajjar
    • 1
  1. 1.Program in Cardiovascular Gene Therapy, Cardiovascular Research Center and Cardiology DivisionMassachusetts General Hospital, Harvard Medical SchoolBoston
  2. 2.Ludwig Boltzmann Institute for Cardiosurgical ResearchUniversity of ViennaAustria
  3. 3.Cardiovascular Research CenterMassachusetts General Hospital-EastCharlestown

Personalised recommendations