Clinical Reviews in Allergy & Immunology

, Volume 30, Issue 1, pp 53–60 | Cite as

Mastocytosis

The great masquerader
  • James S. W. Kong
  • Suzanne Teuber
  • Rosemary Hallett
  • M. Eric Gershwin
Article

Abstract

Variants of mastocytosis can present with puzzling cutaneous and systemic symptoms and signs that can result in an erroneous diagnosis of idiopathic urticaria or idiopathic anayphylaxis. The molecular basis of mastocytosis is now better understood, with updated classification based on distinct growth factor and oncogene abnormalities. Elicitation of a full history and careful attention to the skin examination will usually provide the clinician enough information to deduce that the condition is not simply chronic idiopathic urticaria.

Index Entries

Mast cell tryptase drug allergy c-kit gene mutation urticaria pigmentosa 

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Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  • James S. W. Kong
    • 1
  • Suzanne Teuber
    • 1
  • Rosemary Hallett
    • 1
  • M. Eric Gershwin
    • 1
  1. 1.Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal MedicineUniversity of California at DavisDavis

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