Cell Biochemistry and Biophysics

, Volume 46, Issue 1, pp 43–64

The α-aminoadipate pathway for lysine biosynthesis in fungi

Review

Abstract

This review provides a description of the biochemistry and enzymology of the α-aminoadipate pathway for lysine biosynthesis in fungi. The α-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine dehydrogenase.

Index Entries

α-Aminoadipate pathway lysine biosynthesis in fungi homocitrate synthase Claisen condensation α-aminoadipate reductase saccharopine reductase saccharopine dehydrogenase pyridine nucleotide-linked amino acid oxidoreductase antifungal drugs 

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© Humana Press Inc 2006

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of OklahomaNorman

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