Cell Biochemistry and Biophysics

, Volume 46, Issue 1, pp 1–15 | Cite as

Arrestin interaction with rhodopsin

Conceptual models
  • Anna Modzelewska
  • Slawomir Filipek
  • Krzysztof Palczewski
  • Paul S. -H. Park
Original Article


It is becoming increasingly apparent that G protein-coupled receptors (GPCRs) can exist and function as oligomers. This notion differs from the classical view of signaling wherein the receptor has been presumed to be monomeric. Despite this shift in views, the interpretation of data related to GPCR function is still largely carried out within the framework of a monomeric receptor. Rhodopsin is a prototypical GPCR that initiates phototransduction. Like other GPCRs, the activity of rhodopsin is regulated by phosphorylation and the binding of arrestin. In the current investigation, we have explored by modeling methods the interaction of rhodopsin and arrestin under the assumption that either one or two rhodopsin molecules bind each arrestin molecule. The dimeric receptor framework may provide a more accurate representation of the system and is therefore likely to lead to a better and more accurate understanding of GPCR signaling.

Index Entries

G protein-coupled receptor arrestin oligomerization signal transduction G protein 


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Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  1. 1.International Institute of Molecular and Cell BiologyWarsawPoland and
  2. 2.Department of PharmacologyCase Western Reserve UniversityCleveland

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