Cell Biochemistry and Biophysics

, Volume 43, Issue 3, pp 439–449 | Cite as

Cytoskeletal regulation of nitric oxide synthase

Review Article


The three isoforms of nitric oxide synthase (NOS)—endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS)—colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

Index Entries

Actin microtubules intermediate filaments endothelium transcription 


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Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Yunchao Su
    • 1
  • Dmitry Kondrikov
    • 1
  • Edward R. Block
    • 1
    • 2
  1. 1.Department of MedicineUniversity of FloridaGainesville
  2. 2.Research ServiceMalcolm Randall Veterans Affairs Medical CenterGainesville

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