Cell Biochemistry and Biophysics

, Volume 39, Issue 2, pp 133–144 | Cite as

Antifreeze glycoproteins

Structure, conformation, and biological applications
Review Article


Antifreeze glycoproteins (AFGPs) are a novel class of biologically significant compounds that possess the ability to inhibit the growth of ice both in vitro and in vivo. Any organic compound that possesses the ability to inhibit the growth of ice has many potential medical, industrial, and commercial applications. In an effort to elucidate the molecular mechanism of action, various spectroscopic and physical techniques have been used to investigate the solution conformations of these glycoproteins. This review examines the characterization of AFGPs and potential biological applications relating to stabilization of lipid membranes and vitrification adjuvants.

Index Entries

Antifreeze glycoproteins thermal hysteresis membrane stabilization vitrification 


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Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of OttawaOntarioCanada

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