Cell Biochemistry and Biophysics

, Volume 35, Issue 3, pp 275–288

Caldesmon and smooth-muscle regulation

Review Article

DOI: 10.1385/CBB:35:3:275

Cite this article as:
Albert Wang, C.L. Cell Biochem Biophys (2001) 35: 275. doi:10.1385/CBB:35:3:275

Abstract

Smooth muscles exist in the wall of hollow organs in our body and are responsible for controlling the flow of vital fluids that are essential for the normal function of the cardiovascular, respiratory, digestive, and reproductive systems. Many diseases, such as hypertension, asthma, indigestion, and premature birth, may attribute to malfunction of smooth-muscle contraction. It is therefore important to decipher how smooth-muscle contraction is regulated. This review attempts to give a brief overview of current understanding about the molecular mechanisms of smooth-muscle regulation and, in particular, to discuss possible roles of caldesmon in this regulatory process.

Index Entries

Actin-binding proteins Caldesmon Calmodulin dense body electron microscopy intracellular localization latch state smooth muscle synthetic peptides thin filament-based regulation 

Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  1. 1.Muscle and Motility GroupBoston Biomedical Research InstituteWatertown

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