Biological Trace Element Research

, Volume 98, Issue 3, pp 193–207 | Cite as

Influence of maternal stress on metal-induced pre- and postnatal effects in mammals

A review
  • José L. Domingo
  • Angels Domingo
  • M. Teresa Colomina


Studies in rodents have shown that, during pregnancy, maternal stress from restraint, noise, light, and heat among other factors may be associated with adverse effects on embryo/fetal and postnatal development. Moreover, it is also well known that exposure to certain metal levels during gestation can also cause maternal and developmental toxicity. Because potentially, pregnant women may be concurrently exposed to metals and various types of stress, the influence of maternal stress on the metal-induced adverse pre-and postnatal effects has been investigated for a number of elements. This influence is reviewed here. It is concluded that maternal stress enhances the metal-induced embryo/fetal and developmental toxicity only at doses of the metal which are also clearly toxic to the dam.

Index Entries

Metals stress restraint maternal toxicity development toxicity behavioral toxicity 


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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • José L. Domingo
    • 1
  • Angels Domingo
    • 1
  • M. Teresa Colomina
    • 1
  1. 1.Laboratory of Toxicology and Environmental Health, School of Medicine“Rovira i Virgili” UniversityReusSpain

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