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Iodine and/or selenium deficiency alters tissue distribution pattern of other trace elements in rats

  • Belma Giray
  • Jacqueline Riondel
  • Josianne Arnaud
  • Veronique Ducros
  • Alain Favier
  • Filiz Hincal
Article

Abstract

Tissue distribution of Fe, Mn, Cu, and Zn, the essential trace elements associated with oxidant and/or antioxidant processes, was examined in iodine- and/or selenium-deficient rats (ID, SeD, ISeD). Fe and Mn were the most affected minerals in all types of deficiency states. Mn levels decreased significantly in the liver in all deficiency states (approx 20–30%), in the heart in ID and SeD rats (approx 30–35%) and in the testis in ID rats (approx 15%). Whereas Mn enhancement was noted in kidney (approx 45%) and plasma in SeD and ISeD (approx 20% and 50%, respectively) animals. However, most striking alterations were seen with Fe. Significant elevation of Fe concentrations were observed in all deficiency states in the kidney (approx 90–125%) and heart (approx 20–25%), and in the liver in SeD (approx 35%) and ISeD (approx 75%) rats, whereas significant (approx 20%) Fe enhancement in the testis was observed only in ISeD animals. Lower Cu (approx 10–15%) and higher Zn (approx 10–20%) concentrations in heart tissues in all deficiency states were found; higher Zn (approx 20–35%) in the kidney of SeD and ISeD rats, and lower Cu in the testis of SeD animals were observed. In brain tissue, no alteration was seen in Fe, Mn, and Zn content, however, significantly increased (approx 15–20%) Cu concentrations were noted in all deficiency states. The results of this study indicated that iodine and/or selenium deficiency may modify the distribution and the homeostasis of other minerals.

Index Entries

Selenium iodine thyroid hormones manganese iron copper zinc 

References

  1. 1.
    P. J. Aggett, Physiology and metabolism of essential trace elements: an outline, Clin. Endocrinol. Metab. 14, 513–543 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    H. Vanucchi, Interaction of vitamins and minerals, Arch. Latinoam. Nutr. 41, 9–18 (1991).Google Scholar
  3. 3.
    Y. H. Lee, D. K. Layman, R. R. Bell, and H. W. Norton, Response of glutathione peroxidase and catalase to excess dietary iron in rats. J. Nutr. 111, 2195–2202 (1981).PubMedGoogle Scholar
  4. 4.
    A. G. Abdel Rahim, J. R. Arthur, and C. F. Mills, Effects of dieatary copper, cadmium, iron, molybdenum and manganese on selenium utilization by the rat, J. Nutr. 116, 403–411 (1986).PubMedGoogle Scholar
  5. 5.
    P. M. Moriarty, M. F. Picciano, J. L. Beard, and C. C. Reddy, Classical selenium-dependent glutathione peroxidase expression is decreased secondary to iron deficiency in rats, J. Nutr. 125, 293–301 (1995).PubMedGoogle Scholar
  6. 6.
    M. J. Christensen, C. A. Olsen, D. V. Hansen, and B. C. Ballif, Selenium regulates expression in rat liver of genes for proteins involved in iron metabolism, Biol. Trace Element Res. 74, 55–70 (2000).CrossRefGoogle Scholar
  7. 7.
    R. E. Burch, R. V. Williams, H. K. Hahn, M. M. Jetton and J. F. Sullivan, Tissue trace element and enzyme content in pigs fed a low manganese diet. I. A relationship between manganese and selenium, Lab. Clin. Med. 86, 132–139 (1975).Google Scholar
  8. 8.
    Z. Zhu, M. Kimura, and Y. Itokawa, Mineral status in selenium-deficient rats compared to selenium-sufficient rats fed vitamin-free casein-based or torula yeast-based diet, Biol. Trace Element Res. 37, 219–231 (1993).Google Scholar
  9. 9.
    K. Matsumoto, T. Inagaki, R. Hirunuma, S. Enomoto, and K. Endo, Contents and uptake rates of Mn, Fe, Co, Zn, and Se in Se-deficient rat liver cell fractions, Anal. Sci. 17, 587–591 (2001).PubMedCrossRefGoogle Scholar
  10. 10.
    T. M. Al-Khayat, T. M., Al-Darweesh, and M. S. Islam, The effect of thyroxine, the antithyroid drug propylthiouracil and thyroidectomy on mineral metabolism in rat tissues, J. Clin. Chem. Clin. Biochem. 20, 281–285 (1982).PubMedGoogle Scholar
  11. 11.
    J. W. Oliver, Effect of thyroid state on magnesium concentration of rat tissues, Am. J. Vet. Res. 39, 159–161 (1978).PubMedGoogle Scholar
  12. 12.
    K. O. Adeniyi, O. O. Ogunkeye, and C. O. Isichei, Thyroidectomy and thyroxine administration alter serum calcium levels in rat, Acta Physiol. Hung. 81, 95–99 (1993).PubMedGoogle Scholar
  13. 13.
    D. Behne, A. Kyriakopoulos, H. Meinhold, and J. Kohrle, Identification of type I iodothyronine 5′-deiodinase as a selenoenzyme, Biochem. Biophys. Res. Commun. 173, 1143–1149 (1990).PubMedCrossRefGoogle Scholar
  14. 14.
    W. Croteau, S. I. Whittemore, M. Schneider, and D. L. St Germain, Clonning and expression of cDNA for a mammalian type III Iodothyronine deiodinase, J. Biol. Chem. 270, 16569–16575 (1995).PubMedCrossRefGoogle Scholar
  15. 15.
    M. J. Berry, L. Banu, and P. R. Larsen, Type I iodothyronine deiodinase is a selenocystein-containing enzyme, Nature 349, 438–440 (1991).PubMedCrossRefGoogle Scholar
  16. 16.
    J. R. Arthur and G. J. Beckett, Thyroid function, Br. Med. Bull. 55, 658–668 (1999).PubMedCrossRefGoogle Scholar
  17. 17.
    World Health Organization, Trace Elements in Human Nutrition and Health, WHO, Geneva (1996).Google Scholar
  18. 18.
    V. Ducros and A. Favier, Gas chromatographic-mass spectrometric method for the determination of selenium in biological samples, J. Chromatogr. 583, 35–44 (1992).PubMedCrossRefGoogle Scholar
  19. 19.
    G. J. Beckett, F. Nicol, P. W. H. Rae, S. Beech, Y. Guo, and J. R. Arthur, Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats, Am. J. Clin. Nutr. 57, 240S-243S (1993).PubMedGoogle Scholar
  20. 20.
    N. Chareonpong-Kawamoto and K. Yasumoto, Selenium deficiency as a cause of overload of iron and unbalanced distribution of other minerals, Biosci. Biotechnol. Biochem. 59, 302–306 (1995).PubMedCrossRefGoogle Scholar
  21. 21.
    N. Chareonpong-Kawamoto, T. Higasa, and K. Yasumoto, Histological study of iron deposits in selenium-deficient rats, Biosci. Biotechnol. Biochem. 59, 1913–1920 (1995).PubMedGoogle Scholar
  22. 22.
    D. A. Papanastasiou, D. V. Vayenas, A. Vassilopoulos, and M. Repanti, Concentration of iron and distribution of iron and transferrin after experimental iron overload in rat tissues in vivo: study of the liver, the spleen, the central nervous system and other organs, Pathol. Res. Pract. 196, 47–54 (2000).PubMedGoogle Scholar
  23. 23.
    P. T. Lieu, M. Heiskala, P. A. Peterson, and Y. Yang, The roles of iron in health and disease, Mol. Aspects Med. 22, 1–87 (2001).PubMedCrossRefGoogle Scholar
  24. 24.
    X. Qu, K. Huang, L. Deng, and H. Xu, Selenium deficiency-induced alterations in the vascular system of the rat, Biol. Trace Element Res. 75, 119–128 (2000).CrossRefGoogle Scholar
  25. 25.
    S. S. Sobajic, M. B. Mihailovic, and M. O. Miric, The effects of selenium deficiency, dietary selenium, and vitamin E supplementation on the oxidative status of pig liver, J. Environ. Pathol. Toxicol. Oncol. 17, 265–270 (1998).PubMedGoogle Scholar
  26. 26.
    S. Yetkin, F. Hincal, N. Basaran, and G. Ciliv. Serum selenium status in children with iron deficiency anemia, Acta Haematol. 88, 185–188 (1992).Google Scholar
  27. 27.
    K. Eder, A. Kralik, and M. Kirchgessner, The effect of manganese supply on thyroid hormone metabolism in the offspring of manganese-depleted dams, Biol. Trace Element Res. 55, 137–145 (1996).CrossRefGoogle Scholar
  28. 28.
    N. Q. Liu, Q. Xu, X. L. Hou, et al., The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency, Brain Res. Bull. 55, 309–312 (2001).PubMedCrossRefGoogle Scholar
  29. 29.
    K. Aihara, Y. Nishi, S. Hatano, et al., Zinc, copper, manganese, and selenium metabolism in thyroid disease, Am. J. Clin. Nutr. 40, 26–35 (1984).PubMedGoogle Scholar
  30. 30.
    A. C. Chua and E. H. Morgan, Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat, Biol. Trace Element Res. 55, 39–54 (1996)Google Scholar
  31. 31.
    E. A. Malecki, A. G. Devenyi, T. F. Barron, T. J. Mosher, P. Eslinger and C. V. Flaherty-Craig, Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity, Neurotoxicology 20, 647–652 (1999).PubMedGoogle Scholar
  32. 32.
    D. V. Vayenas, M. Repanti, A. Vassilopoulos, and D. A. Papanastasiou. Influence of iron overload on manganese, zinc and copper concentration in rat tissues in vivo: study of liver, spleen and brain, Int. J. Clin. Lab. Res. 28, 183–186 (1998).PubMedCrossRefGoogle Scholar
  33. 33.
    M. Aschner and J. L. Aschner, Manganese transport across the blood-brain barrier: relationship to iron homeostasis, Brain Res. Bull. 24, 857–860 (1990).PubMedCrossRefGoogle Scholar
  34. 34.
    B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, Clarendon, Oxford (1989).Google Scholar
  35. 35.
    T. Miyamoto, A. Sakurai, and L. J. DeGroot, Effects of zinc and other divalent metals on deoxyribonucleic acid binding and hormone-binding activity of human alpha 1 thyroid hormone receptor expressed in Escherichia coli, Endocrinology 129, 3027–3033 (1991).PubMedCrossRefGoogle Scholar
  36. 36.
    A. Kralik, K. Eder, and M. Kirchgessner, Influence of zinc and selenium deficiency on parameters relating to thyroid hormone metabolism, Horm. Metab. Res. 28, 223–226 (1996).PubMedCrossRefGoogle Scholar
  37. 37.
    H. C. Lukaski, C. B. Hall, and M. J. Marchello. Impaired thyroid hormone status and thermoregulation during cold exposure of zinc-deficient rats, Horm. Metab. Res. 24, 363–366 (1992).PubMedGoogle Scholar
  38. 38.
    M. Ruz, J. Codoceo, J. Galgani, et al., Single and multiple selenium-zinc-iodine deficiencies affect rat thyroid metabolism and ultrastructure, J. Nutr. 129, 174–180 (1999).PubMedGoogle Scholar
  39. 39.
    K. L. Olin, R. M. Walter, and C. L. Keen, Copper deficiency affects selenoglutathione peroxidase and selenodeiodinase activities and antioxidant defense in weanling rats, Am. J. Clin. Nutr. 59, 654–658 (1994).PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Belma Giray
    • 1
  • Jacqueline Riondel
    • 2
  • Josianne Arnaud
    • 2
  • Veronique Ducros
    • 2
  • Alain Favier
    • 2
  • Filiz Hincal
    • 1
  1. 1.Department of Toxicology, Faculty of PharmacyHacettepe UniversityAnkaraTurkey
  2. 2.Laboratory of Biology of Oxidative Stress, Faculty of PharmacyJoseph Fourier UniversityGrenobleFrance

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