Abstract
We investigated the possible differences between the concentrations of selenium in the whole blood and thyroid tissue of patients with thyroid disease. The study comprises 41 women with nodular goiter, 19 women and 2 men with thyroid cancer, 18 women with Graves’ disease, and 7 women with thyroiditis. The concentration of selenium was determined by the TRXRF method. The lowest mean selenium level was achieved in the whole blood of women with Graves’ disease and the highest in the whole blood of healthy people. In the thyroid cancer tissue, we found the lowest concentration of selenium and the highest in the thyroid gland of women with nodular goiter and Graves’ disease. The low selenium levles in the thyroid tissue may increase thyroid cancer risk.
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References
D. G. Barceloux, J. Toxicol. Clin. Toxicol. 37, 145 (1999).
G. F. Coombs and W. P. Gray, Pharmacol. Ther. 79, 179 (1998).
L. Flohe, J. R. Andreesen, R. Brigelius-Flohe, and M. Maiorino, Life 49, 411 (2000).
J. Köhrle, R. Brigelius-Flohe, A. Böck, R. Gätner, O. Meyer, and L. Flohe, Biol. Chem. 381, 849 (2000).
K. Overvad, Selenium and cancer. Role of trace elements for health promotion and disease prevention, in Bibl. Neutr. Dieta 54, 141 (1998).
M. P. Rayman, Lancet 356, 233 (2000).
G. N. Schrauzer, Biol. Trace Element Res. 51, 33 (1992).
M. Vinceti, S. Rovest, M. Bergomi, and G. Vivoli, Tumori 86, 105 (2000).
J. Köhrle, Acta Med. Aust. 23, 17 (1996).
P. Wobrauschek, J. Radiat. Nucl. Chem. 167, 433 (1993).
U. Majewska, J. Braziewicz, D. Banaś, A. Kubala-Kukuś, S. Góźdź, M. Pajek, et al., Nucl. Instrum. Meth. Phys. Rev. B 150, 254 (1999).
A. Kubala-Kukuś, D. Banaś, J. Braziewicz, U. Majewska, S. Mrówczyński, and M. Pajek, X-Ray Spectrosc. 30, 348 (2001).
J. Aaseth, H. Frey, E. Glattre, G. Norheim, J. Ringstad, and Y. Thomassen, Biol. Trace Element Res. 24, 147 (1990).
M. Sanz Alaejos, F. Diaz Romero, and C. Diaz Romero, Nutrition 16, 376 (2000).
A. Kralik, K. Eder, and M. Kirchgessner, Horm. Metab. Res. 28, 223 (1996).
J. Köhrle, Biochime 81, 527 (1999).
E. Glattre, Y. Thomassen, S. O. Thorensen, T. Haldorsen, P. G. Lund-Larsen, L. Theodorsen, et al. Int. J. Epidemiol. 18, 45 (1989).
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Kucharzewski, M., Braziewicz, J., Majewska, U. et al. Concentration of selenium in the whole blood and the thyroid tissue of patients with various thyroid diseases. Biol Trace Elem Res 88, 25–30 (2002). https://doi.org/10.1385/BTER:88:1:25
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DOI: https://doi.org/10.1385/BTER:88:1:25