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Biological Trace Element Research

, Volume 110, Issue 2, pp 97–106 | Cite as

Seminal plasma zinc concentration and α-glucosidase activity with respect to semen quality

  • Minal Mankad
  • N. G. Sathawara
  • Haresh Doshi
  • H. N. Saiyed
  • Sunil Kumar
Article

Abstract

This study was conducted to examine the relationship between the concentration of zinc and neutral α-glucosidase (NAG) with semen quality. Semen samples from 75 male partners of couples who were attending the Obstetrics and Gynecology Department were analyzed for semen quality. Based on sperm count, the subjects were divided into three groups. Zinc and neutral α-glucosidase activity were estimated in seminal plasma. Results showed that mean the α-glucosidase activity was lowest among the azoospermic group with respect to oligozoospermic and normozoospermic groups. Mean zinc levels were also lower among azoospermics compared to oligozoospermic and normospermic groups. The difference was statistically significant (p<0.05). A significant positive correlation was observed between zinc levels and sperm count (r=0.29, p<0.05) and zinc and α-glucosidase activity (r=0.31, p<0.05) in seminal plasma. These results suggest that zinc and neutral α-glucosidase seem to play an important role in human reproduction.

Index Entries

Zinc sperm count seminal plasma semen quality alpha glucosidase 

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References

  1. 1.
    M. G. Hull, C. M. A. Glazener, N. J. Kelley, et al., Population study of cures, treatment and outcome of infertility, Br. Med. J. 291, 1693–1697 (1985).Google Scholar
  2. 2.
    H. W. Jones and J. P. Toner, The infertile couple, N. Engl. J. Med. 329, 1710–1715 (1993).PubMedCrossRefGoogle Scholar
  3. 3.
    D. S. Irvine, Epidemiology and etiology of male infertility, Hum. Reprod. 13, 33–44 (1998).PubMedCrossRefGoogle Scholar
  4. 4.
    S. Kumar, Occupational exposure associated with reproductive dysfunction, J. Occup. Health 46, 1–19 (2004).PubMedCrossRefGoogle Scholar
  5. 5.
    S. E. Chia, C. N. Ong, L. H. Chua, L. M. Ho, and S. K. Tay, Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameter between fertile and intertile men, J. Androl. 21, 53–57 (2000).PubMedGoogle Scholar
  6. 6.
    M. Gavella and V. Lipovac, In vitro effect of zinc on oxidative changes in human semen, Andrologia, 30, 317–323 (1998).PubMedCrossRefGoogle Scholar
  7. 7.
    H. Fuse, T. Kazama, S. Ohta, and Y. Fujiuchi, Relationship between zinc concentrations in seminal plasma and various sperm parameters, Int. Urol. Nephrol. 31, 401–408 (1999).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Carreras and C. Mendoza, Zinc levels in seminal plasma of fertile and infertile men, Andrologia 22, 279–283 (1990).PubMedCrossRefGoogle Scholar
  9. 9.
    WHO, Manual for the Examination of Human Semen and Sperm Cervical Mucous Interaction, 4th ed., Cambridge University Press, Cambridge (1992).Google Scholar
  10. 10.
    R. H. Glass and A. Mrouch, The post-coital test and semen analysis. Fertil. Steril. 18, 314–317 (1967).PubMedGoogle Scholar
  11. 11.
    D. I. Lewis-Jones, I. A. Aird, M. M. Biljan, and C. R. Kingsland, Effects of sperm activity on zinc and fructose concentrations in seminal plasma. Hum. Reprod. 11, 2465–2467 (1996).PubMedGoogle Scholar
  12. 12.
    C. I. Madding, M. Jacob, V. P. Ramsay, and R. Z. Sokol, Serum and semen zinc levels in normozzospermic and oligozoospermic men. Ann. Nutr. Metab. 30, 13–18 (1986).CrossRefGoogle Scholar
  13. 13.
    W. Y. Wong, G. Flik, P. M. Groenenen, et al., The impact of calcium, magnesium, zinc and copper in blood and seminal plasma on semen parameters in men. Reprod. Toxicol. 15, 131–136 (2001).PubMedCrossRefGoogle Scholar
  14. 14.
    Y. C. Lin, T. C. Chang, Y. J. Tseng, et al., Seminal plasma zinc levels and sperm motion characteristics in infertile samples, Changgeng Yi Xue Za Zhi 23, 260–266 (2000).PubMedGoogle Scholar
  15. 15.
    M. B. Sorenson, I. A. Bergdahl, N. H. Hjollund, J. P. Bonde, M. Stoltenberg, and E. Ernst, Zinc, magnesium and calcium in human seminal fluid: relationship to other semen parameters and fertility, Mol. Hum. Reprod. 5, 331–337 (1999).CrossRefGoogle Scholar
  16. 16.
    S. Elzanaty, J. Malm, and A. Giwercman, Visco-elasticity of seminal fluid in relation to the epididymal and accessory sex gland function and its impact on sperm motility, Int. J. Androl. 27, 94–100 (2004).PubMedCrossRefGoogle Scholar
  17. 17.
    A. M. Mahmound, J. Geslevich, J. Kint, et al., Seminal plasma alpha-glucosidase activity and male infertility, Hum. Reprod. 13, 591–595 (1998).CrossRefGoogle Scholar
  18. 18.
    A. F. Zopfgen, S. F. Priem, K. Jung, S. Lenk, S. A. Leoning, and P. Sinha, Relationship between semen quality and the seminal plasma components carnitine, alphaglucosidase, fructose, citrate and granulocyte elastase in infertile men compared with a normal population, Hum. Reprod. 15, 840–845 (2000).PubMedCrossRefGoogle Scholar
  19. 19.
    S. Elzanaty, J. Malm, and A. Giwercman, The impact of epidymal and accessory sex gland function on sperm motility, Hum. Reprod. 17, 2904–2911 (2002).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Minal Mankad
    • 1
  • N. G. Sathawara
    • 1
  • Haresh Doshi
    • 2
  • H. N. Saiyed
    • 1
  • Sunil Kumar
    • 1
  1. 1.Department of Reproductive Toxicology and HistochemistryNational Institute of Occupational Health (ICMR)AhmedabadIndia
  2. 2.Department of Obstetrics and Gynecology, B. J. Medical CollegeCivil HospitalAhmedabadIndia

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