Biological Trace Element Research

, Volume 108, Issue 1–3, pp 197–204 | Cite as

Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3

  • Sebahat Turgut
  • Bünyamin Kaptanoĝlu
  • Günfer Turgut
  • Gülten Emmungil
  • Osman Genç
Original Articles


Humans are constantly exposed to cadmium (Cd) as a result of the increase in air pollution and cigaret use. Zinc (Zn), which is an essential element for the metabolism of and the constituent of many enzymes, causes growth retardation in the deficiency status so at present it is often added to the diet without measuring blood levels of this element. We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I(IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this study. For this purpose, 27 young Wistar albino male rats were divided into three groups. The first group was given 50 mg/L of CdCl2, the second group received 500 mg/L of ZnSO4, and the third group, as a control, received only drinking water for 1 mo. At the end of this period, plasma GH, IGF-I, and IGFBP-3 of the animals were analyzed in the blood obtained. The significance between groups was evaluated with the Mann-Whitney U-test. According to our results, levels of IGF-I and IGFBP-3 in the Cd-administered group were significantly lower than those of controls (p<0.05 and p<0.01 respectively). No statistically significant difference was observed between Zn administered and control groups in terms of all three parameters. These results show that although the addition of Zn to the diet of healthy rats had no effect on the levels of GH, IGF-I, and IGFBP-3, Cd addition lowered the levels of IGF-I and IGFBP-3 but did not change the levels of GH compared to controls.

Index Entries

Cadmium zinc growth hormone insulin-like growth factor I IGF-I insulin-like growth factor binding protein 3 IGFBP 3 


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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Sebahat Turgut
    • 1
  • Bünyamin Kaptanoĝlu
    • 2
  • Günfer Turgut
    • 1
  • Gülten Emmungil
    • 1
  • Osman Genç
    • 1
  1. 1.Department of Physiology, Faculty of MedicinePamukkale UniversityDenizliTurkey
  2. 2.Department of Biochemistry, Faculty of MedicinePamukkale UniversityDenizliTurkey

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