Effects of zinc supplementation in patients with type 1 diabetes
- 164 Downloads
The purpose of this study was to identify the effect of oral zinc supplementation in patients with type 1 diabetes (T1DM) on metabolic control and zinc blood concentrations. The sample consisted of 20 patients with T1DM and a control group (n=17). Metabolic control was evaluated by glycemia at fast, 24 h glycosuria, and HbA1c. Zinc concentrations were measured in plasma and erythrocytes. After the first collection of biological material, oral zinc supplementation was initiated and continued for 4 mo in T1MD patients (T1). Daily dosages were established based on Dietary Recommended Intakes (DRIs), considering zinc intake based on data from other studies previously performed with this population. All analyses were repeated after supplementation (T2). Metabolic control was unsatisfactory, with an HbA1c increase at T2. There was no difference in zinc concentrations in plasma and erythrocytes between patients with T1DM and control. Zinc concentrations in plasma were within the normal range in T1MD before and after supplementation and the control. Zinc concentrations in erythrocyte presented lower than normal values for all groups. A zinc increase in erythrocyte after supplementation was observed in T1DM patients, although without statistical significance. More studies are needed to confirm oral zinc supplementation as nutritional management in diabetes.
Index EntriesZinc supplementation type 1 diabetes metabolic control nutritional assessment
Unable to display preview. Download preview PDF.
- 4.L. F. C. Pedrosa and S. M. F. Cozzolino, Alleraço ~es metabólicas e funcionais do zinco em diabetes mellitus, Arq. Bras. Endocrinol. Metab. 42, 422–430 (1998).Google Scholar
- 6.K. C. M. Sena and L. F. C. Pedrosa, Efeitos da suplementação com zinco sobre o crescimento, sistema imunológico e diabetes: Uma revisão, Rev. Nutr. 18(2), (2005), in press.Google Scholar
- 10.J. M. Tanner and R. H. Whitehouse, Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty, Arch. Dis. Child. 62, 57–62 (1976).Google Scholar
- 11.National Academy of Science, Food and Nutrition Board, Institute of Medicine (USA), Dietary Reference Intakes (DRI) for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Cooper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc, National Academy of Science, Washington, DC (2001)Google Scholar
- 12.M. P. Rodriguez, A. Nazariano, V. Demczylo, et al., A simpler method for the determination of zinc human plasma levels by flame atomic absorption spectrophotometry, Atomic Spectrosc. 10(2), 68–70 (1989).Google Scholar
- 14.R. S. Gibson, Assessment of trace-elements status, in Principles of Nutritional Assessment, R. S. Gibson, ed., Oxford University Press, Oxford, pp. 542–553 (1990).Google Scholar
- 16.C. Ruiz, A. Alegria, R. Barbera, et al., Selenium, zinc and cooper in plasma of patients with type 1 diabetes mellitus in different metabolic control states, J. Trace Elements Med. Biol. 12, 91–95 (1998).Google Scholar
- 17.L. Kennedy, T. D. Mehl, E. Elder, et al., Noenzymatic glycosylation of serum and plasma proteins, Diabetes 31, 52–56 (1982).Google Scholar
- 20.D. Vitoux, J. Arnaud, and P. Chappuis, Are cooper, zinc, selenium inerithrocytes valuable biological indexes of nutrition and pathology? J. Trace Elements Med. Biol. 13, 113–128 (1999).Google Scholar
- 21.L. F. C. Pedrosa, A. Spínola-Castro, M. Matsumoto, et al., Evaluation of zinc in children with type 1 diabetes mellitus, in Trace Elements in Man and Animals, A. M. Roussel, R. A. Anderson, and A. E. Favier, eds., Kluwer Academic/Plenum, New York, pp. 511–513 (2000).Google Scholar