Biological Trace Element Research

, Volume 105, Issue 1–3, pp 1–9 | Cite as

Effects of zinc supplementation in patients with type 1 diabetes

  • Karine Cavalcanti Mauricio de Sena
  • Almeida Dina Maria de Araújo
  • Mirza Medeiros dos Santos
  • Vanessa Teixeira de Lima
  • Lucia de Fátima Campos Pedrosa
Original Articles


The purpose of this study was to identify the effect of oral zinc supplementation in patients with type 1 diabetes (T1DM) on metabolic control and zinc blood concentrations. The sample consisted of 20 patients with T1DM and a control group (n=17). Metabolic control was evaluated by glycemia at fast, 24 h glycosuria, and HbA1c. Zinc concentrations were measured in plasma and erythrocytes. After the first collection of biological material, oral zinc supplementation was initiated and continued for 4 mo in T1MD patients (T1). Daily dosages were established based on Dietary Recommended Intakes (DRIs), considering zinc intake based on data from other studies previously performed with this population. All analyses were repeated after supplementation (T2). Metabolic control was unsatisfactory, with an HbA1c increase at T2. There was no difference in zinc concentrations in plasma and erythrocytes between patients with T1DM and control. Zinc concentrations in plasma were within the normal range in T1MD before and after supplementation and the control. Zinc concentrations in erythrocyte presented lower than normal values for all groups. A zinc increase in erythrocyte after supplementation was observed in T1DM patients, although without statistical significance. More studies are needed to confirm oral zinc supplementation as nutritional management in diabetes.

Index Entries

Zinc supplementation type 1 diabetes metabolic control nutritional assessment 


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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Karine Cavalcanti Mauricio de Sena
    • 1
  • Almeida Dina Maria de Araújo
    • 2
  • Mirza Medeiros dos Santos
    • 3
  • Vanessa Teixeira de Lima
    • 1
  • Lucia de Fátima Campos Pedrosa
    • 1
  1. 1.Deparment of NutritionUniversidade Federal do Rio Grande do Norte, UFRNNatal-RNBrazil
  2. 2.Department of Clinical Analysis and ToxicologicsUniversidade Federal do Rio Grande do Norte, UFRNNatal-RNBrazil
  3. 3.Department of PharmacyUniversidade Federal do Rio Grande do Norte, UFRNNatal-RNBrazil

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