The genetics of fibrodysplasia ossificans progressiva

  • Eileen M. ShoreEmail author
  • George J. Feldman
  • Meiqi Xu
  • Frederick S. Kaplan
Fibrodysplasia Ossificans Progressiva


Fibrodysplasia ossificans progressiva (FOP) is a rare, heritable disorder with infrequent genetic transmission of the condition owing to low reproductive, fitness. The recent identification of several small, additional families with inheritance of classic features of FOP has provided the opportunity to expand positional cloning efforts to identify the mutated gene in FOP through whole-genome linkage nnalyses. Candidate gene studies using both genetic (linkage), and molecular (gene expression) approaches also are contributing to information about the genetic and cellular, causes of FOP.

Key Words

Fibrodysplasia ossificans progressiva (FOP) genetics: inheritance mutation heterotopic ossification autosomal-dominant 


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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Eileen M. Shore
    • 4
    • 1
    • 3
    Email author
  • George J. Feldman
    • 4
    • 3
  • Meiqi Xu
    • 4
    • 3
  • Frederick S. Kaplan
    • 4
    • 2
    • 3
  1. 1.Department of GeneticsThe University of Pennsylvania School of MedicinePhiladelphia
  2. 2.Department of MedicineThe University of Pennsylvania School of MedicinePhiladelphia
  3. 3.The Center for Research in FOP and Related, DisontersThe University of Pennsylvania School of MedicinePhiladelphia
  4. 4.Department of Orthopaedic SurgeryThe University of PennsylvaniaPhiladelphia

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