Applied Biochemistry and Biotechnology

, Volume 83, Issue 1–3, pp 155–162

Idiotypic network dysregulation

A common etiopathogenesis of diverse autoimmune diseases

DOI: 10.1385/ABAB:83:1-3:155

Cite this article as:
Sherer, Y. & Shoenfeld, Y. Appl Biochem Biotechnol (2000) 83: 155. doi:10.1385/ABAB:83:1-3:155


The pathogenesis of autoimmune disease is still an enigma. Whereas the diverse clinical manifestations of many autoimmune diseases cannot be explained by the existence of autoantibodies, idiotypic dysregulation may provide an alternative explanation. Experimental models, serum level changes of pathogenic idiotypes during exacerbation and remission, and the increased expression of pathogenic idiotypes following common infections all support this notion. In this article we review experimental models of autoimmune disease induction (systemic lupus erythematosus, antiphospholipidsyn drome, Goodpasture's syndrome, autoimmune thyroiditis, and vasculitis) by manipulation of the idiotypic network and discuss the utilization of idiotypes for the immunotherapy of autoimmune diseases and other conditions that involve the immune system (e.g., atherosclerosis).

Index Entries

Autoimmunity idiotypes systemic lupus erythematosus 

Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  1. 1.Department of Medicine ‘B’ and the Research Unit of Autoimmune DiseasesSheba Medical CenterTel-Hashomer
  2. 2.Sackler Faculty of MedicineTel-Aviv UniversityIsrael

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